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Epi MT > African Swine Fever > Flashcards

African Swine Fever Flashcards

1
Q

what is referred to epidemic 1 of ASF

A

In 60s, endemic in Sardinia- Genotype 1

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2
Q

What is referred as Epidemic 2 of ASF?

A

07, Caucasus region- genotype 2

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3
Q

ASF found in which animals

A

wild boars & domestic pigs

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3
Q

ASFV name

A

Asfaviridae, asfavirus

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4
Q

ASF virus physical aspect

A

at least 24 genotypes, very big, many genes = many antigens

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5
Q

asfavirus way of infection

A
  • some genes block interferon production & antiviral defense mechanism
  • encodes prot of eukaryotic origin (difficult to differentiate from somatic cells)
    -multiplication in macrophages (block of the IS)
  • prot: induction of Ab BUT none neutralizing ones!
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6
Q

what are the main problem the body encounters against ASFV

A
  • interferon are blocked
  • hidden from IS
  • no neutralizing anitbodies
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7
Q

ASFV genome

A

Ds linear DNA: cytoplasmic inclusion body despite being DNA virus

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8
Q

ASFV polymerase

A

its own, can rep in vector AND swine

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9
Q

ASFV resistancy

A

enveloped BUT high resistance

60° for 30mins

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10
Q

what is the vector of ASFV

A

tick (biological vector)

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11
Q

Africa: transmission of ASFV

A
  • tick-tick (vertical)
  • tick-warthog (dead end host)
  • tick-domestic swine
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12
Q

europe & asia, transmission of ASFV

A

Boar-pig, pig-pig, boar-boar, tick-pig

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13
Q

spreading of ASFV in europe & Asia

A

inf: saliva, nasal discharge (tick) shedding before CS (48hrs)
spreading: airport, raw meat, transport

lesser importance of tick in europe

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14
Q

mortality in acute ASF

A

100%

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15
Q

mortality in chronic ASF

A

<30%

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16
Q

what kind of cycle can be found between warthog- ticks and ticks-ticks?

A

Sylvatic cycle

both asymptomatic carriers (doesnt do anything)

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17
Q

which genotype does O. moubata caries?

A

genotype 1

18
Q

What genotype of ASF does O. erraticus can carrie ?

O: Ornithodorus

A

Genotype 1

19
Q

which genotype of ASF Ornithodorus verrucosus can carry

A

genotype 2

20
Q

ASFV pathogenesis

A

PO/Tick
tonsils, regional Ln
Viraemia (macrophages)
Spleen, lymphatic T., endothel

21
Q

when does the virus of ASF start shedding

A

even 48hrs before start of CS

22
Q

Consequence of a persistent viraemia of ASF?

A

immunosupppression

23
Q

Abs against ASFV

A

6-8 days postinfection
non neutralizing
virus wears membrane of macrophage like a raincoat (Abs can’t reach it)
persistent
immune complex formation

24
Q

Obvious clinical sign of ASF

A

Abortion

in case of DD for abortion => ASF should be said first

25
Q

ASF incubation time

A

4-19 dys (usually 2-7dys)

26
Q

Peracute CS of AFS

A

rapid death without rapid fever, CS or patho changes

27
Q

Acute ASF CS

A

fever 40-42°
no appetite
dyspnea (bloody serous discharge)
conjunctivitis
diarrhoea (with coagulated blood)
CNS signs
skin haemorrhages, cyanotic ears
lung oedema

28
Q

Subacute ASF CS

A

mild symptoms (milder acute form)
longer course (4wks)
more frequent CNS symptoms
death within 14-30dys

29
Q

chronic ASF CS

A

recurrent fever, athritis
focal skin necrosis & ulcers in protuding parts
resp signs

death as late as 2-15 mths

30
Q

T/F

chronic case of ASF easy to diagnose

A

false

31
Q

Patho of ASF

A

acute course: damage of blood vessels
gallbladder and choleductus region show gelatinous inflitration
oedematous lung

32
Q
A
33
Q

muscle necrosis is a patho finding of ASF?

A

Yes, chronic form

34
Q

how to differantiate between ASF & CSF

A

RT-PCR can

35
Q

diag methods for ASF

A

RT-PCR
Hemadsorption

36
Q

DD of ASF

A

CSF
acute paratypus
PDNS
swine erysipelas

37
Q

difference between CSF & ASF

A
  • ASF has more serious haemorrhagic appearance
  • Higher mortality
  • Enlarged spleen
  • Oedema in the wall of the gall bladder
38
Q

Prevention of ASF

A

no spe prevention (animals WILL die)
preventive zone 3km
Observation zone 10km (can be resolved after 45 dys)
ban on import of live pigs, airports, ports & border station

39
Q

Treatment of ASF

A

no vaccine

(2 ASF vaccine dvlped in vietnam but not to WOAH standards)

40
Q
A
41
Q
A
42
Q
A

Epi MT (15 decks)

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