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Epi MT > CircoViradae > Flashcards

CircoViradae Flashcards

1
Q

Shape of circoviridae

A

Icosahedral

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2
Q

Diameter of circoviridae

A

17-25nm

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3
Q

Genome of circoviridae

A

Single strand
circular DNA
nucleic acid also infective (difficult to inactivate)

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4
Q

how many genes does circoviridae have

A

3-4

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5
Q

where does circoviridae replicate

A

in dividing cells (using polymerase enzyme)

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6
Q

does circoviridae have good antigens

A

yes

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7
Q

how resistant is circoviridae

A

VERY, outside can be infectious for months

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8
Q

PCV1

A

non pathogenic

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9
Q

PCV2

A

Responsible for PCVD (or in background)

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10
Q

heat deactivation of circoviridae

A

80° for 1h

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11
Q

cell type circoviridae is found in

A

immune cells

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12
Q

PCV2 & PCV3

A

same disease different genome

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13
Q

PCV4

A

similar to mink circovirus

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14
Q

pathogenesis of Porcine circovirus

A

oronasal route (or other)
–> Rep in Immune c –> Viraemia
–> Imunosupression OR PMWS

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15
Q

predisposing factors of PCVD

A

environment

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16
Q

diseases connected to PCV

A
  • subclinical inf. (immune sup.)
  • PCV2 systemic D. (new PMWS)
  • PCV2 resp D
  • PCV2 enteric D
  • PCV2 repro D (most imp)
  • PDNS (porcine dendritic néphropathy syndrome)
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17
Q

PMWS age

A

1,5 - 4 months

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18
Q

PMWS symptoms

A
  • diarrhea, phtisis
    progressive weight loss
    jaundice
    rough hair
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19
Q

PMWS patho

A

swollen lymph nodes (inguinal & mesenteric)
haemorrages
pneumonia
(myocardial replication)

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20
Q

PDNS age

A

from 1,5 months (30-100kg)

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21
Q

PDNS symptoms

A

red spots on skin
progressive weight loss
haemorrages, oedema

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22
Q

PDNS patho

A

Red, enlarged LN
Glomerulonephritis
Haemo in renal cortex

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23
Q

PRDC age

A

4-7 months

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24
Q

PRDC symptom

A

fever
lethargy
resp

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25
Q

PRDC patho

A

interstitial bronchopneumonia
peribronchial fibrosis

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26
Q

Repro disorders age

A

pregnant

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27
Q

Repro disorders symptoms

A

SMEDI

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28
Q

Repro disorders pathology

A

fetal myocarditis (also detected in liver c & macropages)

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29
Q

can the activated immune system help the development of the disease (PCV2)

A

yes

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30
Q

how to control PCV2 disease

A

vaccine protection

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31
Q

animals susceptible of PCV2

A

domestic pigs and reservoir species

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32
Q

PDNS pathogenesis

A

Type 3 hypersensitivity

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33
Q

what happens in sows infected with PCV2 before day 70

A

sever lesions : abortus, mummification & embryonic death

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34
Q

what happens in sows infected with PCV2 after day 70

A

immune response of fetus but repro pb remains

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35
Q

Where is PRDC more frequent than PMWS

A

North America

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36
Q

PRDC diagnosis

A
  • Ab resistancy
  • Histological lesions of lungs
  • PCV2 detected in lungs
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37
Q

how to detect PCVD

A

- immunohistochemistry
- IF
- PCR

ELISA: for IgM in recent infections

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38
Q

Types of vaccines used for PCVD

A

Inactivated
Recombinant

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39
Q

what is the sow vaccine

A

protects from repro pb
enough protection for piglets in first few weeks

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40
Q

when is the highest uptake of the PCV virus for piglets

A

first few weeks of age

41
Q

What is the piglet vaccine?

A

protect during and after weaning

42
Q

which species can naturally be inf-ected with PCV

A

domestic pigs
wild boars
cattle
rodents (in pig farms)

43
Q

PCV3?

A

similar CS, no immune complexes (no PDNS)
repro disease

all over the world

44
Q

PCV4 ?

A

role in co infections:
- PCV2
- PCV3
- PRRSV
- PEDV
- Aujesky

china + south korea

45
Q

what kind of infection is possible for dog Circovirus

A

subclinical
clinical
co-infection
asymptomatic

46
Q

Patho of dog circovirus

A

pale mucosa
bloody stool
hemorrhagic in SI
splenomegaly

47
Q

which animals can be infected by dog circovirus

A

dog, wolf, fox, badger

48
Q

Avian circovirus CS

A

immunossupression

49
Q

avian circovirus diseases

A
  • Beak and feather virus
  • pigeon circovirus
  • goose circovirus
50
Q

BFD which animals

A

young birds, below 3 years

51
Q

BFD replication

A

in dividing cells (feather follicules)

horizantal and vertical transmission

52
Q

Acute BFD CS

A
  • lethargy, anorexia
  • resp signs
  • vomit, diarrhea

death within 2-4 weeks (secondary inf)

53
Q

chronic BFD CS

A

lesions obvious after moulting, loss feather
feather and beak deformitites

can go on for years or die within 1

surving birds are carriers and shedders

54
Q

Pigeon circovirus age

A

1- 12 months

55
Q

PiCV CS

A

Lethargy, anorexia, beak & feather deformities

race performance decrease

56
Q
A
57
Q

Acute PiCV

A

similar to BFD

death in 2-5 days

58
Q

which cells are destroyed in PiCV

A

spleen, thymus and bursa

59
Q

Goose Circovirus

GoCV age & CS

A

1 week old & slow growth, feather formation

60
Q

Chicken infectious anaemia agent

A

Anelloviridae/Gyrovirus

61
Q

CAV CS

A

anaemia
immune suppression

62
Q

CAV affected animals

A

ONLY chickens (few weeks old)

63
Q

Epi of CAV

A

vertical (egg,sperm)
horizantal (direct contact, feces)

shedding with egg up to 2 months

64
Q

Age of CAV

A

below 3 weeks: disease/severe
over 3 weeks: mild

65
Q

pathogenesis of CAV

A

PO > intestine (resp) > viraemia > dividing cells

66
Q

mainly in which cells does CAV infect?

A

T cells

67
Q

how can we differentiate bursitis and CAV

A

mainly B cells in bursitis

68
Q

clinical CAV

A
  • Anaemia-dermatitis
  • 10-14 day old
  • rare

vertical transmission

69
Q

Subclinical CAV

A
  • resistance with age
  • frequent
  • decrease productivity

horizantal transmission

70
Q

CAV clinical signs & age

A

up to 1 month
incubation 7-10 days
not typical clinical signs

71
Q

CAV pathology

A

haemorrhages, in gizzard and proventriculus
thinner blood
anemia

72
Q

histo path of CAV

A

Myeloid and lymphoid cells destroy

73
Q

diagnosis of CAV

A

virus isolation on lymphoid cells
IF, PCR

74
Q

DD of CAV

(Diferential diagnosis)

A
  • infectious bursitis
  • newcastle disease
  • avian influenza
  • viral inclusion body hepatitis
75
Q

Vaccination of hens against CAV

A

12-15 wo

76
Q

CAV vaccine

A

in young: inactivated virulent
live, moderately attenuated

by drinking

77
Q

papillomaviridae diameter

A

40-55nm

78
Q

papillomaviridae shape

A

icosahedral

79
Q

papillomaviridae resistance

A

VERY, inf. for month in evironment

80
Q

papillomaviridae genome

A

double stranded, linear DNA

different than PCV & CAV

81
Q

can papillomaviridae replicate in tissue culture

A

no, needs keratin

82
Q

T/F

papillomaviridae uses viral transcriptase

A

True

83
Q

T/F

papillomaviridae is stenoxen but not oncogene

A

F, stenoxen and oncogene

84
Q
A
84
Q

Bovine papillomatosis types

A

6

85
Q

BPM that infects horses

A

1,2

86
Q

BPV in the skin all over the body

A

1,2,3

87
Q

BPV in the intestines

A

4

88
Q

BPV in skin of udder

A

5,6

89
Q

where can be found infected virion of BPV

A

stratum corneum

virion assembly in stratum granulosum

90
Q

Incubation, spreading & intake of BPV

A
  • 1-2month in young animals
  • direct contact, fly vector (all over the world)
  • trauma, errosion (skin, mucosa)
91
Q

Clinical signs of BPV

A

nodules: near eye, horn base, abdomen, neck, dug, withers

rare: oesophagus, oral cavity

92
Q
A
93
Q

BPV treatment

A

surgical removal, if irritating

not AUTOVACCINES bc food producing animals

94
Q

Horse papillomavirus

A

EPV 2 types
on head & neck
iatrogenic spreading

under 3 years old

95
Q

Horse sarcoid cause

A

BPaV 1&2
head, abdomen & hoof
agressive but no metastasis

horse cannot spread virus (rep cycle is stopped)

96
Q

Dog /Cat papillomavirus can be found where

A

oral cavity, genitalia

97
Q

Dog /Cat papillomavirus treatment

A

autovaccine

98
Q
A

Epi MT (15 decks)

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