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Epi MT > ParvoViridae > Flashcards

ParvoViridae Flashcards

1
Q

Parvoviridae diameter

A

18-26 nm

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2
Q

Parvoviridae Shape

A

Icosahedral

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3
Q

Parvoviridae resistancy

(envelop ?)

A

Non-enveloped
- VERY strong resistancy

infectious for months in evironment

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4
Q

Parvoviridae genome

A

single stranded, linear DNA

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5
Q

Parvoviridae replication

A

uses cellular polymerase enzyme:
- rep in dividing cells or usage of helper viruses

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6
Q

Parvoviridae good or bad antigen?

A

Good antigen

Stenoxen

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7
Q

SMEDI stands for

A
  • stillbirth
  • mummification
  • embryonic death
  • infertility
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8
Q

Porcine parvovirus disease less common where?

A

Autralia and new-zealand

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9
Q

Pahtogenesis of Porcine parvovirus disease

A

intake: PO
Rep: in dividing cells
viraemia (1-7 dys)
fetus-across placenta (2weeks after inf)
shedding: feces, saliva & sperm

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9
Q

Porcine parvovirus disease structural proteins facts

A

3 structural prot: VP1,2&3
VP2: neutralizing

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10
Q

Porcine parvovirus disease 5 biotypes

A
  1. NADL-2: apatogen
  2. Classical PPV1: susceptible sows -SMEDI
  3. Kresse’s strain: dermatitis, death of immunocompetent fetus
  4. Strain with skin symptoms
  5. Coinfection with PCV-2: PMWS or PRDC
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11
Q

How long does maternal immunity protect against Porcine parvovirus disease

A

up to 6 months

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12
Q

Porcine parvovirus disease virus can cross the placenta in seropositive sows?

A

No

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13
Q

How long does the antibody production lasts for in case of Porcine parvovirus disease

A

9-10 months

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14
Q

Porcine parvovirus disease clinical signs

A

SMEDI

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15
Q

Porcine parvovirus disease clinical signs in pregnant sows

A
  • smaller than normal litter

PPV unlikely if at least 8 piglets alive

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16
Q

Porcine parvovirus disease clinical signs in Embryos and fetus

A
  • to 30 dys: death, resorption
  • 30-70dys: death -> mummification
  • after 70dys : weak & mummified fetus, myoclonia congenita
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17
Q

Can adults suffer from resp sign from PPV infection

A

rarely

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18
Q

Arbotus typical in PPV infected sows

A

no

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19
Q

after infection from PPV how long does immunity last for?

A

life long

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20
Q

what pb can a sow with life long immunity encounter later in life

A

repro problems every 3-4 years

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21
Q

pathology of PPV

A
  • not uniquely characteristic
  • subcutan haemorrages
  • mummification
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22
Q

serology diagnostics of Porcine parvovirus disease

A
  • VN
  • HAI
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23
Q

Direct virus detection diagnostics of Porcine parvovirus disease

A

PCR
HA
virus isolation

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24
Q

diagnostics methods for Porcine parvovirus disease

A
  • serology
  • direct virus detection
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25
Q

differential diagnostic of Porcine parvovirus disease

A
  • PRRS
  • PCV2
  • Leptospirosis
  • Brucellosis
  • CSF
  • AUjesky
  • FMD
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26
Q

vaccine of Porcine parvovirus disease

A

inactivated (live) combined

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27
Q

vaccination protocol of Porcine parvovirus disease

A

vaccination after 6 months of age, 1x or 2x before breeding
repeat 1x every year

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28
Q

originally how many Porcine parvovirus disease serotype? now how many?

A

At first 1, now 7 PPV

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29
Q

Parvorirus enteritis of dogs infection between 3-8 weeks

A

sudden death
myocardial damage
high mortality within 2-3 days

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30
Q

Parvorirus enteritis of dogs infection after 8 weeks

A

Enteritis

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31
Q

Parvorirus enteritis of dogs infects whiwh animals

A

dog
wolf
fox
canidae

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32
Q

which Canine parvovirus strain can infect cats?

A

CPV-2, only “a” subtypes

(10% of panleukopenia cases)

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33
Q

Pathogenesis of Parvorirus enteritis of dogs

A

intake: PO
Rep: lymphoid tissue around throat, GALT
Viraemia
organs with fast cell division: crypt cells, myocardial (young animals), bone marrow, spleen, thymus, ln)
massive shedding in faeces

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33
Q

Parvorirus enteritis of dogs clinical signs

A
  • no spe signs
  • acute gastro-enteritis

outcome depends on age and immunity

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34
Q

Diagnostic method of Parvorirus enteritis of dogs

A

virus detection form feces
Antibody detection

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35
Q

virus detection from feces of Parvorirus enteritis of dogs

A

rapid tests: positive for 10-15 days after live vaccines

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36
Q

Antibody detection of Parvorirus enteritis of dogs

A

rapid tests: sera
(maternal immunity and vaccine!)

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37
Q

DD between Parvorirus enteritis of dogs and rotavirus

A

milder, haemorrhagic diarrhea is unusual

38
Q

target of Parvorirus enteritis of dogs

39
Q

target of coronavirus in dog Intestine

A

TIP of villi

40
Q

target of rotavirus

41
Q

treatment of Parvorirus enteritis of dogs

A

treat clinical condition
AB for sec inf
quarantine
hyperimmune sera

42
Q

prevention of Parvorirus enteritis of dogs

A

vaccine: inactivated
maternal Ab up to 3-4 months
(hyperimminue sera before CS)

43
Q

Cat Panleukopenia virus

44
Q

Cat Panleukopenia pathogenesis

A

intake: PO
rep: lymphoid tissues around throat
viraemia
rep in lymphopid cells (leukopenia), crypt cells, myocardium, crosses placenta
shedding from faeces

45
Q

Cat Panleukopenia clinical signs

A
  • high temperature
  • vomiting, diarrhea
  • young: may die before diarrhea

outcome depends on age and immunity

46
Q

can cerebellar hypoplasia be a pathological finiding in CAPV infected cat

A

yes, caused by intrauterin or perinatal infection

47
Q

Diagnotic method of Cat Panleukopenia

A

virus detection from feces:
IF, PCR

48
Q

DD of Cat Panleukopenia

A
  • infectious rhinotracheitis (herpes virus)
  • infectious peritonis (coronavirus)
  • diarrhea (calicivirus)
49
Q

Cat Panleukopenia prevention

A

inactivated vaccine
maternal Ab 3-4 months
(hyperimmune serum best before CS)

combined vaccine : rhinotracheitis, calicivirus

50
Q

Mink Parvovirus enteritis pathogenesis

A

same as cats and dogs

50
Q

Aleutian mink disease susceptible species

A

Mink, ferret

mink of aleutian genotype is more susceptible

(lack in antigen presentation)

51
Q

young mink CS in Aleutian mink disease

A

interstitial pneumonia

52
Q

older mink CS in Aleutian mink disease

A

hypergammaglobulinaemia
glomerulonephritis

53
Q

Aleutian mink disease pathogenesis

A

intake: PO
rep: lymphoid tissue around throat
Viraemia
organs with fast cell division
shedding after 3/4 days

54
Q

which typer of hypersensitivity is the Aleutian mink disease

A

typer 3 hypersensitivity

55
Q

CS of aleutian mink disease

A

anorexia, bloddy faeces, nervous signs

56
Q

lethality of aleutian mink disease

A

aleutian: 50%
other colors : 5%

57
Q

pathology observed in aleutian mink disease

A
  • increased plasma cell count
  • glomerulonephritis
  • arteritis
58
Q

detection of aleutian mink disease virus

A

PCR, Isolation

59
Q

aleutian mink disease vaccine

A

no vaccine, general epidemiological preventive

60
Q

Derzsy’s disease other names

A

goose influenza
goose hepatitis
goose parvovirus enteritis

61
Q

Derzsy’s disease in which animals

A

goose and muskovy duck
(duck able to shed the virus but have no clinical signs)

62
Q

which family does the goose parvovirus come from?

A

dependoparvovirus
(does not need helper virus)

63
Q

Pathogenesis of goose parvovirus

A

intake: PO
replication: small intestinal epithelium
viraemia
parenchymal organs
shedding in faeces

64
Q

spreading of goose parvovirus

A

horizontal
vertical

65
Q

horizontal spread of goose parvovirus

A

feces, recovered but long term shedding geese

66
Q

Vertical spread of goose parvovirus

A

subclinical infection of parents
infected old goose
infected eggs:
- embryo dies
- hatches infected

67
Q

after how much time does an infected goose with parvovirus has no clinical signs

68
Q

Clinical signs of goose parvovirus in susceptible gooslings?

A
  • cold like symptoms
  • diarrhea
  • convulsions
  • ascites

infection at hatching or day 1

death within 2-3 days

69
Q

Clinical signs of goose parvovirus in partially protected goslings?

A

feather growing problems (receding hair)
ascites

signs appear at the end of 2nd week

70
Q

Clinical signs of goose parvovirus around day 13-15?

A

diarrhea, excicosis

(intact liver and heart)

71
Q

Pathology of goose parvovirus?

A
  • ascites (fibrinous)
    - ball shaped heart, tiger stripes
  • haemorrhages on membranes
  • hepatitis
  • pericarditis & perihepatitis
  • enteritis
72
Q

DD of goose parvovirus

A

Riemerellosis
Hemorrhagic Nephritis enteritis of geese

73
Q

prevention of goose parvovirus

A
  • obligatory to vaccinate (attenuated, inactivated or subunit)
  • Re-vaccinate layers, esp before end of laying period
  • passive protection (hyperimmune serum) for day old goslings
74
Q

Duck parvovirus

A

similar to Derzsy
BArbari duck, muscovy duck but does not infect geese

75
Q

CS of duck parvovirus

A
  • diarrhea
  • weakness in legs
  • nervous system
  • chronic: growth stops, feather growing pbs
76
Q

Duck parvovirus pathology

A

Enlarged liver
muscles look like cooked meat
ball shaped heart
ascites

77
Q

Shrt beak and dwarfism syndrome is associated with which virus

A

duck parvovirus
(muscovy duck)

genetic variant of MDPV & GPV

78
Q

Polyomaviridae diameter

79
Q

Polyomaviridae shape

A

icosahedral

80
Q

Polyomaviridae resistancy

A

non enveloped:
- VERY strong

onfectious for months in the environment

81
Q

Polyomaviridae genome

A

double stranded, linear genome

82
Q

Polyomaviridae structural proteins

A

VP1, VP2, VP3 (sometimes VP4)

replication associated proteins

83
Q

which transcriptase does Polyomaviridae use?

84
Q

Polyomaviridae is stenoxen?

A

yes, except birds

85
Q

Polyomaviridae is oncogene?

86
Q

French Molt

Budgerigar Fledgling Disease Virus affected species

A

Parrots, falcon and finch

87
Q

Budgerigar Fledgling Disease Virus CS and survival CS

A

Oedema, ascites, nephritis & hepatitis, haemorrages
dvlpmt & growth stops, feather growing problems

88
Q

Hemorrhagic Nephritis Enteritis of geese pathogenesis

A

Intake: PO, intranasal
rep: lymphoid tissues around throat
VIraemia
virus rep: blood endothelium, bursa, kidney and intestinal epithelium
shedding in faeces

89
Q

Hemorrhagic Nephritis Enteritis of geese CS

A
  • CNS (shaking of head and neck)
  • diarrhea
  • Chronic: uric acid crystals
  • elderly : sheds virus with no symptoms

CS starts few hours BEFORE death

90
Q

Hemorrhagic Nephritis Enteritis of geese pathology

A
  • oedema
  • ascitis
  • haemorrhagic nephritis
  • gout
  • necrotizing haemorrhagic enteritis
  • haemorrages around the body
91
Q

Hemorrhagic Nephritis Enteritis of geese histopath!

A
  • replication in endothelium
92
Q

Hemorrhagic Nephritis Enteritis of geese prevention

A

farm specific vaccine to breeders
vaccine (inactivated BFDV)

Epi MT (15 decks)

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