CaliciViruses

Question 1

Calicivirus genome

Answer 1

ssRNA (subgenomic mRNAs)

Question 2

Calicivirus euryxen or stenoxen

Answer 2

stenoxen

Question 3

Calicivirus antigenicity

Answer 3

good

Question 4

main diseases caused by Calicivirus

Answer 4

Vesivirus:
- vesicular exanthema of swine
- feline calicivirus Infection

Lagovirus:
- rabbit haemorrhagic disease
- european brown hare syndrome

Question 5

Calici virus

norviruse & sapovirus genus

Answer 5

food-born human gastroenteritis
no cross protection

Question 6

Vesicular exanthema of swine history/occurence

Answer 6

absent in swine BUT present in seals in pacific coast of America

Question 7

Vesicular exanthema of swine causative agent

Answer 7

Vesivirus genus
seal (natural hosts)/pigs

Question 8

Vesicular exanthema of swine epizzotiology

Answer 8

inf: raw meat
swine shed by saliva, excretes
transmision with raw pork
survives in environment

Question 9

Vesicular exanthema of swine CS

Answer 9

lethargy, vesicles: mouth, snouts, limbs-lameness
lesions heal rapidly
mortality in piglets
seals: skin lesions, abortion

Question 10

Vesicular exanthema of swine diagnosis

Answer 10

not notifiable disease but differentiate from FMD
PCR, ELISA

Question 11

Vesicular exanthema of swine control & prevention

Answer 11

heat treatment of meat (seafood) before feeding to swine

Question 12

Feline calicivirus infection serotypes

Answer 12

only one, but antigenic variants

Question 13

Feline calicivirus infection epizootiology

Answer 13

shed: excreta
transmission by direct contact
long term carriers & continuously shedder cats (persisting inf. in tonsils and nasopharyngeal mucosa)
FIV infection facilitates infection

Question 14

Feline calicivirus infection pathogenesis

Answer 14

• oronasal
• pharynx
• viraemia
• lungs, mouth, throat, pads, joints (visceral organs, very virulent strains)
• shedding in saliva, faeces & urine

Question 15

Feline calicivirus infection CS

Answer 15

erosions in oral cavity, margin of tongue, nose, pads (heals in 3 wks)
mild resp & conjunctival signs
lameness (has been observed after vaccination)

Question 16

Feline calicivirus infection mortality

Answer 16

low, but exciccosis, secondary bact inf.

Question 16

Feline calicivirus infection virulent systemic FCV CS

Answer 16

severe systemic syndrome
vasculitis, face & pad oedema, resp, icterus
more severe in adults (in vaccinated cats too)

Question 17

Feline calicivirus infection chronic stomatitis CS

Answer 17

lymphoplasmatic stomatitis & gingivitis complex

Question 18

Feline calicivirus infection DDx

Answer 18

Feline rhinotracheitis
bordetella
chlamydophila

Question 19

Ribavirin is a treatment of Feline calicivirus infection

Answer 19

false, in vitro efficient , in vivo toxic

Question 20

how long can maternal antibodies last for against Feline calicivirus infection

Answer 20

10-14wks

Question 21

Feline calicivirus infection vaccines

Answer 21

attenuated and inactivated vaccines
primary vacc: 9 and 12wks old
vaccine can protect for 1 yr
protects from signs but not infection

Question 22

Rabbit haemorrhagic disease occurence

Answer 22

worldwide

Question 23

Rabbit haemorrhagic disease pathogenesis

Answer 23

PO, air, conjunctival
viraemia
propagation in liver
vasculitis

Question 24

Rabbit haemorrhagic disease CS

Answer 24

liver dystrophy thrombo-embolia in airways and visceral organs haemorrhages

Question 25

Rabbit haemorrhagic disease mortality

Answer 25

up to 100%

Question 26

Rabbit haemorrhagic disease virus 1

Answer 26

resistent in environment cannot be propagated in cell culture CS in older animals ## Footnote mortality 70-90%

Question 27

Rabbit haemorrhagic disease virus 2

Answer 27

rabbit and hare longer incubation younger rabbit serologically different to 1

Question 28

# Lagovirus europaeus European brown hare syndrome virus

Answer 28

only hare hepatic necrosis and death

Question 29

European brown hare syndrome CS

Answer 29

hyperacute: none, death acute: foamy/ bloody discharge, mucosal cyanosis terminal opisthotonus

Question 30

European brown hare syndrome shedding

Answer 30

via fecease & excreta- very contageous a few virion is sufficient for infection by conjunctival route ## Footnote direct transmission

Question 31

Rabbit haemorrhagic disease (European brown hare syndrome ) diagnosis

Answer 31

**notifiable** high mortality RT-PCR

Question 32

Rabbit haemorrhagic disease (European brown hare syndrome ) treatment

Answer 32

no treatment vaccination: inactivated vaccine at 4-5wks old, 1x/year