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Epi MT > AdenoViridae > Flashcards

AdenoViridae Flashcards

1
Q

Antigenic properties of adenoviruses

A
  • strong antigens
  • surface projections (fibers)
  • cross reaction with genera (serogroup)

sero group in canine AdenoV important for vaccination

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2
Q

Biological properties of adenovirus

A
  • wide distribution
  • diverse pathogenicity
  • oncogenic effect
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3
Q

Adenovirus genome and replicating enzyme used

A

doubles stranded DNA
uses own polymerase enzyme

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4
Q

Which famous canine disease does adenovirus cause?

A

Rubarths disease (1947)

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5
Q

Infectious canine hepatitis pathogen

A

CAdV-1

Canine Adeno Virus 1

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6
Q

FOx encephalitis pathogen

A

CAdV-1

Canine Adeno Virus 1

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7
Q

Occurance of CAdV-1

A

worldwide

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8
Q

CAdV-1 cause which disease?

A

Canine infectious hepatitis
fox encaphalitis

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9
Q

CAdV-1 pathogenesis

A

Intake: PO,conjunctiva
P. Rep: Tonsils, peyer’s patches
Viraemia
Liver,kidneys, eyes (bleu eye D)
brain (fox)
Shedding: urine (up to 6months)

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10
Q

What typoe of hypersensitivity can CAdV-1 cause

A

Type 3

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11
Q

Peracute clinical signs of CAdV-1

A

death within 1-2 days

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11
Q

clinical signs of acute CAdV-1

A

fever over 40° (3-5 dys)
(1-2 wks) oedema, convulsions, uveitis

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12
Q

in which case can the “blue eye disease” occur?

A

chronic case of CAdV-1

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13
Q

can CAdV-1 cause mucosal haemorrhages, coag problems?

A

yes

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14
Q

CAdV-1 pathology

A
  • haemorrages
  • enlarged, yellow liver
  • nuclear inclusion bodies (cowdry A)
  • gall bladder oedema
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15
Q

diagnostic method for CAdV-1

A
  • lab test (leucopenia, ALT,AST,ALP, bilirubinuria, DIC)
  • direct virus detection (PCR)
  • serology (can be positive in case of vaccination so not used)
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16
Q

Prevention of CAdV-1

A

attenuated (because of sero groups) and inactivated CAdV-1
attenuated CAdV-2
every 2 or 3 years

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17
Q

fox encaphalitis CS, diagnostic & DD

A
  • nerval signs
  • PCR
  • Rabies, distemper
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18
Q

Canine infectious laryngotracheitis causative agent

A

CAdV-2

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19
Q

what is Canine infectious laryngotracheitis

A

mild febrile disease of dogs with upper resp tract inflammation

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20
Q

clinical manifestation of Canine infectious laryngotracheitis in which dogs?

A

young mainly

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21
Q

Canine infectious laryngotracheitis is part of which disease

A

kennel cough

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22
Q

CS of Canine infectious laryngotracheitis

A

mild fever
nasal discharge
dry coughing

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23
Q

Canine infectious laryngotracheitis pathogenesis

A

air born inf
P . Rep: upper resp mucosa
rhinitis, laryngitis tracheobronchitis, bronchiolitis

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24
Q

Canine infectious laryngotracheitis treatment

A

symptomatic
Ab for co infections

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25
Q

Canine infectious laryngotracheitis prevention

A
  • avoid crowded environment
  • polyvalent vaccines, from 2-3 month
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26
Q

AdenoVirus pneumoenteritis can affect

A

calves and sheeps and lambs raised intensively

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27
Q

what is AdenoVirus pneumoenteritis in calves

A

mild disease of 1-4 mO calves, with nasal discharges, coughing and diarrhea

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27
Q

AdenoVirus pneumoenteritis in calves causative agent

A
  • Mastadenovirus genus
  • Barthadenovirus
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28
Q

Mastadenovirus replicates where?

A

bovine kidney

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29
Q

Barthadenovirus replicates where?

A

bovine testicules

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30
Q

AdenoVirus pneumoenteritis in calves pathogenesis

A

Intake: PO, airborne
P rep: Multiplication in tonsils
Viraemia
- respiratory & enteric mucosal epithelia

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31
Q

AdenoVirus pneumoenteritis in calves CS age

A

6-8 wks
or without colostrum: 3-4 wks

32
Q

AdenoVirus pneumoenteritis in calves CS

A
  • coughing
  • salivation
  • mild diarrhea
    Co infection: pneumonia
33
Q

BAdV-10

A

in New Zealand & Norther Ireland
haemorrhagic gastroenteritis, haemorrages in renal cortex, bladder & trachea

34
Q

AdenoVirus pneumoenteritis in calves diagnostic

A

PCR

35
Q

AdenoVirus pneumoenteritis in calves prevention

A

improve keeping conditions
check colostrum uptake

36
Q

Adenovirus pneumoenteritis in lambs pathogenesis

A

same as in calves

37
Q

Adenovirus pneumoenteritis in lambs CS

A

mainly resp signs
also haemorraghic-necrotic enteritis(OAdV-4)

38
Q

Adenovirus pneumoenteritis in lambs frequent complication in rams

A

urolithiasis

39
Q

Biotechnologies of adeno Viruses

A

used as vector to express inserted foreign genes (because big enough)
- rabies vaccine for foxes
- SARS-CoV-2 vaccine for hu

40
Q

Which diseases are caused by Aviadenovirus genus

A
  • Inclusion body hepatitis
  • Hepatitis hydropericardium syndrome
  • Quail Bronchitis
  • Avian gizzard erosion
41
Q

Infection of Aviadenovirus

A

germinative & horizantal infection

42
Q

Aviadenovirus diagnosis

A

virus detection
antibody detection

43
Q

method used for diagnosis of Aviadenovirus

A

PCR

44
Q

Inclusion body hepatitis (IBH) susceptible species

A

chicken, turkey, pigeon & goose

45
Q

Inclusion body hepatitis (IBH) can be seen with another syndrome

A

hydropericardium syndrome

46
Q

Inclusion body hepatitis (IBH) affects mainly which animals

A

3-6 weeks old broilers

47
Q

Inclusion body hepatitis (IBH) clinical signs

A
  • anaemia
  • diarrhea

weakness, similar to hepatitis, hydropericardium

48
Q

Inclusion body hepatitis (IBH) histopath

A

nuclear inclusion bodies

49
Q

Inclusion body hepatitis (IBH) pathology

A

liver: enlarged, pale, necrotic foci
heart & skeletal muscle: petechiae

50
Q

Hepatitis hydropericardium syndrome affects which animal

A

chicken

(goose, pigeon, duck, quail, ostrich)

51
Q

Hepatitis hydropericardium syndrome can be seen in which age group

A

3-6 weeks broilers

52
Q

Hepatitis hydropericardium syndrome was described first in

A

Pakistan then india (lychee disease)

53
Q

Hepatitis hydropericardium syndrome pathology

A
  • hydropericardium
  • lung oedema
  • enlarged kidney
  • pancreas : necrotic foci
  • heart skeletal muscl, haemorrhages
54
Q

Hepatitis hydropericardium syndrome histopathology

A

nuclear inclusion bodies

55
Q

Avian gizzard erosion (AGE) affects which animals & what age

A

Chicken, 3-6 weeks old

(rarely in layers and broiler parent flocks)

56
Q

Avian gizzard erosion (AGE) clinical signs

A
  • inappatence
  • decreased body weight gain & growth of flock is uneven
  • anaemia
  • decreased egg prod
57
Q

Avian gizzard erosion (AGE) patho

A

degenaration of keratin layer of gizzard
haemorrages and ulcers in the mucosal membrane

58
Q

Avian gizzard erosion (AGE) histopath

A

nuclear inclusion bodies

59
Q

Siadenovirus genus diseases

A
  • haemorrhagic enteritis
  • avian adenoviral splenomegaly
  • marble spleen disease
60
Q

Haemorrhagic enteritis (HEV) is seen in which animals

A

turkeys older than 4 weeks

(usually 6-11 week old growers)

61
Q

Haemorrhagic enteritis (HEV) clinical signs

A

immunosuppressive!
varaible (no signs but sudden death can appear)
- bloody diarrhea

62
Q

Haemorrhagic enteritis (HEV) type of infection

A

horizantal

63
Q

Haemorrhagic enteritis (HEV) pathogenesis

A
  • po/ fecal
  • intestinal epithelial cells
  • viraemia
  • bursa of fabricus, spleen, blood vessel damage
  • haemorrhages; immunusuppression
64
Q

Haemorrhagic enteritis (HEV) diagnosis

A

PCR
Elisa

65
Q

Haemorrhagic enteritis (HEV) DD

A
  • Avian influenza, Newcastle disease
  • turkey coronavirus
66
Q

Haemorrhagic enteritis (HEV) prevention

A

attenuated, live vaccine

67
Q

Marble spleen disease (MSD) is seen in which animals

A

Phaesants, 3-8 months old

68
Q

Marble spleen disease (MSD) clinical signs

A

acute resp signs

69
Q

Marble spleen disease (MSD) pathology

A
  • enlarged, marbled spleen
  • lung oedema

(no intestinal lesion)

70
Q

Avian adenovirus splenomegaly (AAS) general aspects

A

found in broilers
similar to phaesant disease (not as severe)
patho: liver & spleen enlarged

70
Q

Barthadenovirus genus disease

A

egg drop syndrome

71
Q

Egg drop Syndrome (EDS) causative agent

A

duck adenovirus
duck/geese: only resp signs
quails: same CS as chickens

72
Q

Egg drop Syndrome (EDS) type of infection

A
  • Vertical (in the egg)
  • Horizantal (with faeces)
73
Q

Egg drop Syndrome (EDS) pathogenesis

A
  • PO/germinative infection
  • rep: in lymphoid tissues & epithelial cells of oviduct/uterus
  • serous-mucous secretion, egg shell deformities
  • shedding: secretion + faeces in the cloaca
74
Q

Egg drop Syndrome (EDS) clinical signs

A
  • diarrhea (10-30% of flock)
  • decreased egg prod
  • soft/thin/pale shelled egg

peak of signs at laying (3-7 weeks)

75
Q

Egg drop Syndrome (EDS) pathology

A

no characteristic signs (lesions in the oviduct)

76
Q

Egg drop Syndrome (EDS) DD

A

decresed egg prod: avian influenza, newcastle disease
egg shell deformities: infectious bronchitis, avian metapneumovirus

77
Q

Egg drop Syndrome (EDS) vaccination

A

inactivated vaccine before laying periode

(yolk immunity –> lower number of infected bird via verticle route)

78
Q

EDS in gosling

A

Acute respiratory disease
rarely clinical signs

79
Q

Acute respiratory disease in gosling caused by EDS
patho

A

rhinitis, tracheobronchitis

Epi MT (15 decks)

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