Post-Mi occurrences Flashcards

1
Q

complications 0-4 hrs post MI (4)

A
  1. arrhyhtmia
  2. HF
  3. cardiogenic shock
  4. death
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2
Q

complications 12-24hrs post MI (4)

A
  1. arrhythmia
  2. HF
  3. cardiogenic shock
  4. death
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3
Q

what are the time brekadowns of post-MI? (6)

A
  1. 0-4 hrs
  2. 4-12 hrs
  3. 12-24 hrs
  4. 1-3 days
  5. 3-14 days
  6. 2wks to several months
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4
Q

when does early coagulative necrosis start?

A

4-12 hrs

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5
Q

what does neutrophil migration start?

A

12-24 hrs

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6
Q

what causes contraction bands?

why?

A

reperfusion injury 2/2 free radical damage

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7
Q

complications 1-3 days post-MI (1)

A

fibrinous pericarditis

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8
Q

when do you see extensive coagulative necrosis w/tissue surrounding infarct with neturophils around it

A

1-3 days

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9
Q

when do you see macrophages and granulation tissue at margins?

A

3-14 days

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10
Q

complications 3-14 days post MI (4)

A
  1. free wall rupture –> tamponade
  2. papillary muscle rupture –> MR
  3. IV septal rupture 2/2 macrophage degradation
  4. LV pseudoaneursym
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11
Q

what’s a LV pseudoaneurysm

A

mural thrombus plugs hole in myocardium … it’s a time bomb

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12
Q

when is the contracted scar complete?

- what does heart look like grossly at this point?

A

2 wks to several months

- gray-white

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13
Q

complications 2wks - several months post-MI (4)

A
  1. Dressler syndrome
  2. HF
  3. arryhtmia
  4. true ventricular aneurysm
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14
Q

what’s Dressler syndrome

A

autoimmune pericarditis

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15
Q

microscope changes 0-4 hrs post MI

A

nothing

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16
Q

microscope changes 4-12 hrs post MI (5)

A
  • early coagulative necrosis
  • release of necrotic cell contents into blood
  • edemea
  • hemorrhage
  • wavy fibers
17
Q

microscopic changes 12-24 hrs post MI (2)

A
  1. neutrophil migration starts

2. reperfusion injury may cause contraction bands (2/2 ROS)

18
Q

microscopic changes 1-3 days post MI (2)

A
  1. extensive coagulative necrosis

2. tissue surrounding infarct shows inflammation with neutorphils

19
Q

microscopic changes 3-14 days post MI (2)

A
  1. marcophages

2. granulation tissue at margins

20
Q

microscopic changes 2 wks to months post MI (1)

A
  1. contracted scar complete