hormones and crap

Question 1

vasoactive intestinal peptide (VIP)

1) where secretion
2) action
3) presentation

Answer 1

1) pancreatic islet cells and neurons in GI mucosa
2) relaxes GI smooth muscle; inhibits gastric H secretion; stimulates pancreatic bicarb and chloride secretion
4) Excess: WDHA syndrome (pancreatic cholera) WATERY DIARRHEA, Hypokalemia, Achlorhydria

Question 2

CCK

1) where secretion
2) action

Answer 2

1) I-cells of proximal small bowel mucosa in response to fatty acids and monoglycerides
2) stimulates secretion of pancreatic enzymes and bicarbonate, gallbladder contraction, inhibition of gastric emptying

Question 3

Secretin

1) where secreted
2) action

Answer 3

1) duodenal S-cells in response to duodenal acidity and FA’s

2) increases pancreatic and biliary bicarbonate secretion an decreases gastric acid secretion

Question 4

Gastrin

1) where secreted
2) action

Answer 4

1) G-cells of stomach mucosa
2) stimulates gastric acid production and growth of gastric mucosa

a/w Zollinger Ellison syndrome (PUD)