Hepatitis

Question 1

HbsAg

how long must it last for it to be considered chronic infection?

Answer 1

detectable during acute infection

persistence after 6 months implies chronic infection

Question 2

Anti-HBs

- what does it mean

Answer 2

appearance indicates resolution of acute infection

confers long-term immunity

Question 3

Anti-HBc IgM

Answer 3

present during acute infection and window phase when both HBsAg and anti-HBs absent

Question 4

Anti-HBc IgG

Answer 4

detectable w/anti-HBs and anti-HBe after recovery from acute infection

• present w/out anti-HBs in chronic infection
• not present after vaccination (only anti-HBs seen)

Question 5

HBeAg

Answer 5

appears after HBsAh during acute infection
marker of viral replication activity
detectable in chronic infection with high infectivity

Question 6

Anti-HBe

Answer 6

present after recovery from acute infection
HBeAg/anti-HBe seroconversion indicates transition of chronic infection from high to low viral replication and infectivity