Muscle / Rheum Flashcards
Polymyositis
1) what regions affected
2) what seen on bx
3) characteristic findings
1) weak proximal muscles (shoulders, girdle)
2) MHC Class I over-expression in myocytes –> CD8-mediated muscle damage
3) serum: anti-Jo-1 antibodies
Polymyalgia rheumatica
1) regions affected
2) s/s’s
3) a/w?
1) bilateral stiffness of shoulder and pelvic girdle
2) feverm wt loss, increased ESR
3) temporal arteritis
Myasthenia gravis
1) what sxs prominent
2) w/activity, worse or better?
3) antibodies
1) extraocular muscle weakness
2) worse
3) anti-AchR
Lambert Eaton
1) what sxs
2) w/activity, worse or better?
3) antibodies
1) weak
2) better
3) anti presyn CaCh
Rheumatoid factor
IgM antibody specific for Fc of self-IgG
forms IC’s that circulates and deposits in synovium and cartilage –> activates complement –> inflammation
Paget’s disease of bone
- presents with what
- excessive activity of what
- caused by what in childhood
- pathology
- deformity in bony area + hearing loss
- excessive osteoclastic bone resorption
- paramyxovirus infection of osteoclast
- very large osteoclasts with up to 100 nuclei
Osteoclasts in Paget’s disease need what differentiating factors (2)
M-CSF
RANK-L
Osteomyelitis in childhood
- mode of infection
- pathogen
- typical location
- hematogenous during bacteremia
- staph aureus or GAS
- long bones
osteomyelitis in sickle cell pts
- mode of infection
- pathogen
- typical location
- hematogenous seeding to infarcted bone
- salmonella or staph aureus
- long bones
osteomyelitis in Pott disease
- mode of infection
- pathogen
- typical location
- hematogenous seeding from lungs
- mycobacterium tuberculosis
- vertebrae
osteomyelitis in DM
- mode of infection
- pathogen
- typical location
- contiguous spread from infected foot ulcer
- polymicrobial
- bones of feet
osteomyelitis in recumbent immobile pts
- mode of infection
- pathogen
- typical location
- contiguous from pressure sores
- polymicrobial
- sacrum and heels
osteomyelitis in recent trauma/ortho surg pts
- mode of infection
- pathogen
- typical location
- direct inoculation
- polymicrobila
- variable
Rheumatoid arthritis
- more specific maker than RF?
anti-cyclic citrullinated peptide (anti-CCP)
Reactive arthritis
- what is it
- who does it tend to affect
- typically asymmetric arthritis of large joints after infection with Campylobacter, Shigella, Salmonella, Yersinia, Chlamydia, or Bartonella
- HLA-B27 positive individuals
