Pharmacology - Cytochrome P450 stuff

Question 1

Inducers of cytochrome P450 (9)

Answer 1

1. chronic alcohol use
2. modafinil
3. st. john’s wort
4. phenytoin
5. phenobarbitol
6. nevirapine (NNRTI)
7. rifampin
8. grieofulvin (anti-fungal)
9. carbamazepine (anti-convulsant, mood stabilizer)

“Chronic alcoholic, St. Modafinil induces Pheny’s Phenobarbitol, Never RIFusing GRIEsy Carbamazepines”

Question 2

Inhibitors of cytochrome P450 (12)

Answer 2

1. acute alcohol use
2. gemfibrozil (anti-lipid by activating PPAR-alpha)
3. ciprofloxacin
4. isoniazid
5. grapefruit juice
6. quinidine
7. amiodarone
8. ketoconazole
9. macrolides
10. sulfonamides (sulfa drugs: abx and thiazide)
11. cimetidine (H2-rec antagonist for heartburn)
12. ritonavir (antiretroviral protease inhibitor)

“A cute alcoholic GEM Cipped Iced Grapefruit juice QUIckly, Amiacably, Keeping macrolidic sulfonic histamine antagonists and antiretrovirals”

Question 3

Substrates of Cytochrome P450 (8)

Answer 3

1. anti-epileptics
2. anti-depressants
3. anti-psychotics
4. anesthetics
5. theophylline
6. warfarin
7. statins
8. OCPs

“Three anti-aesthetics threaten war on statins and OCPs”

Question 4

Sulfa drugs (8)

Answer 4

1. Probenecid
2. Furosemide
3. Acetazolamide
4. Celecoxib
5. Thiazides
6. Sulfonamide abx
7. Sulfasalazine
8. Sulfonylureas

Popular FACTSSS

Question 5

Sx’s of sulfa allergies (7)

Answer 5

1. fever
2. UTI
3. Stevens Johnson syndrome
4. Hemolytic anemia
5. Thrombocytopenia
6. Agranulocytosis
7. Urticaria

Question 6

mneumonic for inducers of cyt p450 (9)

Answer 6

“Chronic alcoholic, St. Modafinil induces Pheny’s Phenobarbitol, Never RIFusing GRIEsy Carbamazepines”

1. chronic alcohlic
2. St john’s wort
3. modafinil
4. phenytoins
5. phenobarbitool
6. nevirapine
7. rifampin
8. griseofulvin
9. carbamazepines

Question 7

mneumonic for inhibitors of cyt p450 (12)

Answer 7

“A cute inhibited alcoholic GEM Cipped Iced Grapefruit juice QUIckly, Amiacably, Keeping macrolidic sulfonic histamine antagonists and antiretrovirals”

1. acute alcohlic
2. gemfibrozil
3. ciprofloxain
4. INH
5. grapefruit juice
6. amiodarone
7. quinidine
8. ketokonazole
9. macrolides
10. sulfonamides
11. cimetidie (histamine rec antagonist)
12. ritonavir (antiretroviral)

Question 8

mneumonic for substrates of cyt p450 (8)

Answer 8

“Three anti-aesthetics threaten war substrating statins and OCPs”

1. anti-psychotic
2. anti-depressant
3. anti-epileptic
4. anesthesia
5. warfarin
6. theophylline
   7 statins
7. ocps

Question 9

mneumonic for sulfa drugs (8)

Answer 9

Popular FACTSSS

1. probenecid
2. furosemide
3. acetazolamide
4. celecoxib
5. thiazides
6. sulfonamide abx
7. sulfasalazine
8. sulfonylurea