Polycystic kidney disease

Question 1

What are the types of polycystic kidney disease?

Answer 1

Autosomal dominant- most common cause of inherited kidney disease
Autosomal recessive- underdeveloped kidneys, not associated w long lifespan

Question 2

What is the presentation pf polyctsic kidney disease?

Answer 2

HAematuria 
Recurrent UTIs
Abdo pain
REnal stones
Hypertension
Enlarged kidneys 
CKD
Extra-renal

Question 3

What are the extra-renal manifestations of polycystic kidney disease?

Answer 3

Liver cysts
Cysts in other organs
CV disease
Berry aneurysm- often causing subarachnoid haemorrhage

Question 4

What screening is done for polycystic kidney disease?

Answer 4

Abdo US

Question 5

What bloods should be done for polyctsic kidney disease?

Answer 5

FBC, U&E, proteins

Anaemia and uraemia

Question 6

What is the preferred imaging for polyctsic kidneys?

Answer 6

Abdo CT

Question 7

What is the diagnostic criteria for polyctsic kidney disease?

Answer 7

FH and
-<30= 2 cysts, unilateral or bilateral
-30-59= 2 cysts on both kidneys
.>60= 4 cysts on both kidneys

Question 8

What is the management of polyctsic kidneys?

Answer 8

Dialysis/kidney transplant

Autosomal dominant- tolvaptan