AKI Flashcards
What is AKI?
Reduction in renal function following insult to the kidneys
How is AKI defined?
Any 1 of
- increase in serum creatinine
- —by >26.5 in 48 hours OR
- —to 1.5x baseline, known or assumed in last 7 days
- urine volume <0.5ml/kg/hr
What are the 3 most common causes of AKI?
Dehydration
Sepsis
Nephrotoxic drugs
What are 3 pre renal causes of AKI?
ISchaemia
Hypovolaemia
Heart failure
What are the renal causes of AKI?
Toxins Acute glomerulonephritis Acute tubular necrosis= most common renal cause Acute interstitial nephritis Rhabdomyelosis Tumour lysis syndrome Multiple myeloma
What are the post renal causes of AKI?
Calculi Clot Malignancy Stricture Fibrosis Prostate disease
What toxins can cause AKI?
ACEi NSAIDs Diuretics Some antibiotics- esp gentamicin, penicillin Radiocontrast
What are the risk factors for AKI?
CKD Other organ failure Previous AKI Nephrotoxic drugs >75 yo Sepsis Major surgery
How is AKI prevented?
Prompt treatment of possible causes
Optimise and monitor volume status and U&Es
Avoid potential toxins, esp where kidney function is already decreased
What are the signs and symptoms of AKI?
Early= asymptomatic Signs and symptoms relating to cause Uraemia= fatigue, loss of appetite, headache, N&V BP changes Arrythmia
What investigations are done for AKI?
FBC, U&Es, LFTs
ABG
Urinalysis
Renal US
What are the management principles of AKI?
Supportive
Treat complications
Dialysis if necessary
What supportive care if given in AKI?
Fluid balance
Stop nephrotoxic drugs
Treat cause
What is an important complication to recognise and treat in AKI?
Hyperkalaemia
How is hyerkalaemia in AKI managed?
Stabilise myocardium- IV calcium gluconate
Shift K+= salbutamol, insulin-dextrose
Dialysis
Diuresis