Acute tubular necrosis Flashcards

1
Q

What is acute tubular necrosis?

A

Necrosis of tubular epithelial cells

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2
Q

What is the histology of acute tubular necrosis?

A

Tubular epithelium necrosis, dilatation of tubules, and necrotic cells obstructing lumen

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3
Q

What are the causes of acute tubular necrosis?

A

Toxic

Ischaemic

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4
Q

What are the toxic causes of acute tubular necrosis?

A

Drugs- esp gentamicin
Myoglobin- secondary to rhabdomyolysis
Radiocontrast

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5
Q

What investigations are done for acute tubular necrosis?

A

Muddy brown casts in urine= pathognomonic

Raised urea, creatinine and potassium

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6
Q

What is the most common renal cause of AKI?

A

Acute tubular necrosis

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7
Q

What is the management of acute tubular necrosis?

A

Treat cause

Supportive

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8
Q

What is the prognosis for acute tubular necrosis?

A

Reversible in early stages

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9
Q

What is the presentation of acute tubular necrosis?

A

Hypotensive, tachycardia
Generally unwell
Oliguria, anuria
Dark coloured urine

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