Platelet Inhibitors Flashcards
List cox 1 inhibitor
Aspirin
List Receptor P2Y12 (ADP receptor) antagonists
Grel ending and tic start Clopidogrel Ticragrelor Prasugrel Ticloopidin
List Glycoproteins iib/iiia receptor antagonist
Abciximab
Eptifibatid
Tirofiban
Which platelet inhibitor is given IV
Glycoprotein iib/iiia receptor antagonist
Aspirin first line drug for
First line for prevention and treatment of arterial thrombotic disorders
Aspirin indications
Ischemic heart disease angina pectoris and MI
Transient cerebral ischemia
Ischemic stroke
Unwanted aspirin effects
GI irritation and ulcer
Aspirin asthma
Hemorrhagic stroke
Clopidogrel and prasugrel mechanism of action
Irreversibly inhibits ADP induced aggregation, both are prodrugs
Ticragrelor difference than clopidogrel
Not a prodrug and binds reversible and is the only one cleared by the kidneys
What is used in patients who can’t tolerate aspirin
Ticlopidine
Ticlopidine indications
- patients who can’t tolerate aspirin
- prevention of transient cerebral ischemia
- prevention of stroke with prior cerebral thrombotic events
Ticlopidine adverse effects
Neutropenia and agranulocytosis
Which receptor P2Y12 antagonist is used for prevention of ischemic events
Clopidogrel
Which receptor P2Y12 antagonist is used for prevention of TIA
ticlopidine
Which receptor P2Y12 antagonist is used for acute coronary symptoms
All except ticlopidine
Which receptor P2Y12 antagonist is used for percutaneas coronary intervention
All except ticlopidine
Mechanism of action of GP iib/iiia receptor antagonist
Bind to receptor making a blockade of fibronogen binding to GP iib/iiia do no aggregation
GP iib/iiia receptor antagonist clinical uses
Adjacent to percutaneous coronary intervention
What can GP iib/iiia receptor antagonist be combined with
Combined with heparin and followed by dual antiplatelet therapy
What do we give for ACS and PCI
DAPT dual antiplatelet therapy
How long before surgery should aspirin be stopped
7 days
How long before surgery should clopidogrel be stopped
5 days
Thrombolytic agents mechanism of action
Dissolve blood clots by promoting conversion of plasminogen to plasmin
List first generation fibrinolytics
Urokinase and streptokinase
List seconds generation fibrinolytics
Altepase and tissue plasminogen activator
List third generation fibrinolytics
Reteplase and teneceteplase
Which thrombolytics have the longest half life
Alteplase and tenecteplase
Thrombolytic agents indications
- Used in acute myocardial infarction within 12 hours of onset(earlier the better)
- Acute thrombotic stroke
Which fibrinolytic is fibrin selective
Alteplase - activates only plasminogen bound to fibrin in a thrombus
Antidote for fibrinolytic system
Aminocarproic acid and tranexamic acid
Iron replacement therapy
Ferrous sulfate 200-400 mg
Acute iron intoxicity
Deferoxamine IV
