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Pharmacology > drug interactions > Flashcards

drug interactions Flashcards

1
Q

Effect of interactions of Doxycycline &

Calcium carbonate

A

Decreased absorption of oral doxycycline

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2
Q

Mechanism of interaction of Doxycycline &

Calcium carbonate

A

Doxycycline chelates calcium cations to produce insoluble and unabsorbable complex

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3
Q

Effect of interactions of Ketoconazole &

Ranitidine

A

Decreased absorption of oral ketoconazole

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4
Q

Mechanism of interaction of Ketoconazole &

Ranitidine

A

Ranitidine decreases gastric acidity, which in turn inhibits absorption of ketoconazole

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5
Q

Effect of interactions of Metformin & Proton pump inhibitors

A

Decreased absorption of oral metformin resulting in metformin intolerance

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6
Q

Mechanism of interaction of Metformin & Proton pump inhibitors

A

PPI inhibits OCT1, which is needed for metformin oral absorption

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7
Q

beneficial drug-drug interactions at the absorption stage

A

lidocaine + norepinephrine

Norepinephrine shrinks blood vessels preventing lidocaine from being absorbed and enhancing its local action

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8
Q

Effect of interactions of Levodopa & Protein-rich diet

A

Reduced brain distribution of levodopa

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9
Q

Mechanism of interaction of Levodopa & Protein-rich diet

A

Levodopa-aminoacids competition for a transporter

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10
Q

Effect of interactions of Loperamide & Verapamil

A

Enhanced brain distribution of loperamide

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11
Q

Mechanism of interaction of Loperamide & Verapamil

A

Verapamil inhibits P-gp, which effluxes loperamide from the brain

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12
Q

Effect of interactions of Aspirin & Phenytoin

A

Enhanced but shortened action of phenytoin

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13
Q

Mechanism of interaction of Aspirin & Phenytoin

A

Aspirin displaces pehnytoin from plasma proteins.

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14
Q

beneficial drug-drug interactions at the stage of distribution

A

verapamil + antidepressant drugs in some patients

Verapamil might enhance brain deposition of some antidepressants

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15
Q

Effect of interactions of Carbamazepine & Warfarin

A

Enhanced metabolism of warfarin, reduced plasma concentration of warfarin

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16
Q

Mechanism of interaction of Carbamazepine & Warfarin

A

Carbamazepine is a CYP inhibitor

17
Q

Effect of interactions of Simvastatin & Grapefruit juice

A

Inhibited metabolism of simvastatin, increased plasma concentration of simvastatin

18
Q

Mechanism of interaction of Simvastatin & Grapefruit juice

A

Ingredients of grapefruit juice are CYP inhibitors

19
Q

Effect of interactions of Cimetidine & Metformin

A

Reduced renal tubular secretion of metformin, increased plasma concentration of metformin

20
Q

Mechanism of interaction of Cimetidine & Metformin

A

Cimetidine inhibits OCT2

21
Q

beneficial drug-drug interactions at the stage of elimination

A

Cobicistat is the only marketed drug used only to increase systemic exposure of antiretroviral drugs by inhibiting CYP.

Pharmacology (33 decks)

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