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Pharmacology > Migranie > Flashcards

Migranie Flashcards

1
Q

What are the main features of migraine

A 
POUND 
Pulsatile headache 
One day duration 
Unilateral 
Nausea 
Disabling
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2
Q

What does acute treatment of migraine do

A

Help manage the pain

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3
Q

What does prophylaxis of migraine do

A

Keep headache from happening

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4
Q

What are the acute treatments of migraine

A

Triptans
Ergot alkaloids
Common analgesic drugs

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5
Q

How is mild to moderate migraine pain treated

A

NSAIDs and Butorphanol

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6
Q

How is severe migraine pain treated

A

Triptans and ergot alkaloids - mimic serotonin to mimic vasoconstriction

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7
Q

What are triptans

A

Agonists at 5-HT1B and 5HT1d receptors

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8
Q

List the triptans

A 
End with triptan
Sumatriptan
Rizatriptan
Naratriptan
Zolmitriptan
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9
Q

When are triptans given

A

In moderate to severe pain or when mild symptoms don’t go away with analgesics

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10
Q

Mode of administration of triptans

A

Oral
But if the person suffers from a lot of vomiting and nausea we can give them as
Nasal spray of SUMA

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11
Q

When do we move on to ergot alkaloids

A

When triptans don’t work

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12
Q

List ergot alkaloids

A

Ergotamine and dihydroergotamine

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13
Q

What are ergot alkaloids

A

Non selective 5HT agonists

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14
Q

Ergot alkaloids contraindications

A

Pregnancy

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15
Q

Migraine first line prophylaxis

A

B-blockers - propanol and metoprolol

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16
Q

Which CCB is used for migraine prophylaxis

A

Verapamil

17
Q

Which TCAs is used for migraine prophylaxis

A

Amitriptyline

18
Q

How is Botox used in migraine prophylaxis

A

Blocking sensation

19
Q

Ergot alkaloids and triptans side effects

A

Rebound headache

Leads to angina and chest discomfort in patients with CAD

20
Q

What is CGRPs

A

Calcitonin gene related peptide - antagonist/antibodies for migraine prophylaxis

21
Q

What are CGRPs used for

A

Migraine prophylaxis

22
Q

List CGRPs and their mechanism of action

A

Galcanezumab, fremanezumab - target CGRP

Erenumab(target CGRP receptors)

23
Q

What drugs are used for erectile dysfunction

A

First line - oral PDE5 inhibitors

24
Q

PDE5 inhibitors mechanism of action

A

Increases levels of CGMP which leads to smooth muscle relaxation

25
Q

List PDE5 inhibitors and their onset

A 
Suffix FIL 
Avanafil - 15 to 30 mins
Sildenafil - 30-60 mins
Vardenafil - 30-60 mins 
Tadalafil - 60-120 mins (up to 36 hours)
26
Q

PDE5 inhibitors contraindications

A

Contraindicated with organic nitrates

Pharmacology (33 decks)

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