Pharmacokinetics Flashcards
1
Q
Effect of ph on drug absorption
A
Uncharged particles ——> absorbed better
2
Q
What are most drugs made of
A
Weak acids or weak bases
3
Q
Where are acidic drugs absorbed
A
They get absorbed more rapidly in acidic environment HA—> A- + H+
4
Q
Where are basic drugs absorbed more rapidly
A
In alkaline environment
BH+ —> B + H+
5
Q
What is VD
A
Volume of distribution
6
Q
How to calculate VD
A
Amount of drug in body(in systemic circulation) // plasma concentrations at T=0
7
Q
What happens to the drug when it enters in the body
A
It is distributed in to 3 functionally distinct compartments
