Pharmacodynamics

Question 1

Effect of medications on the body

Answer 1

Pharmacodynamics

Question 2

How strong a medication binds to its receptor

Answer 2

Affinity

Question 3

An increase in AFFINITY leads to

Answer 3

an increase in POTENCY

Question 4

The amount of medication to elicit an effect

Answer 4

Potency

Question 5

An increase in affinity leads to an increase in potency which also leads to

Answer 5

An decrease in the dose

Question 6

Maximal effect of the drug

Answer 6

Efficacy (Emax)

Question 7

The smaller the EC50

Answer 7

The higher the potency

Question 8

If two drugs have the same Emax they also have the same

Answer 8

Efficacy

Question 9

Two drugs with the same Emax but the one with the low EC50 is

Answer 9

More potent

Question 10

All available receptors bound to an agonist

Answer 10

Full agonist

Question 11

Lower intrinsic activity (lower emax)

Answer 11

Partial agonist

Question 12

An antagonist which is reversible and can be overcome with an increase in Ligands

Answer 12

Competitive antagonist

Question 13

An antagonist that binds to an allosteric site changing shape of the receptor

Answer 13

Non competitive antagonists

Question 14

What does a full antagonist do to a full agonist

Answer 14

Influences the dose needed to elicit a maximal response but doesn’t effect the extent of the maximal response

Question 15

Full agonist with a non competitive antagonist

Answer 15

Drops the emax

Question 16

When a maximal response of a drug seen without binding to all the receptors

Answer 16

Presence of spare receptors

Question 17

Up regulation of receptors occurs when ?

Answer 17

Receptor activation is lower than normal

Question 18

Ability of a cell to produce a response will drop RAPIDLY, can occur with initial dose.

Answer 18

Desensitisation

Question 19

Ability of a cell to produce a response will drop after continued stimulation gradually

Answer 19

Tolerance

Question 20

dose of a drug observed to yield half-maximal efficacy.

Answer 20

ED50

Question 21

dose of a drug observed to yield half-maximal toxicity.

Answer 21

TD50

Question 22

is a quantitative measurement of the relative safety of a drug.

Answer 22

Therapeutic index

Question 23

TD50/ED50

Answer 23

Therapeutic index

Question 24

Low TI

Answer 24

Bad

Question 25

High TI

Answer 25

GOOD

Question 26

what is the difference between an agonist and an inverse agonist

Answer 26

an inverse agonist is a drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist. … An agonist increases the activity of a receptor above its basal level, whereas an inverse agonist decreases the activity below the basal level.