PharmExam4- composition/MOA

Question 1

active metabolite Nortriptiline

Answer 1

amtriptiline

Question 2

most potent, selective inhibitor of NE reuptake

Answer 2

imipramine

Question 3

most selective for inhibition of serotonin reuptake

Answer 3

clomipramine

Question 4

unique: NO action on transporters; EXTREMELY strong affinity for histamine

Answer 4

trimipramine

Question 5

D2 receptor antagonist; mixed antidepressant and neuroleptic

Answer 5

amoxapine

Question 6

unique- binds NE but HIGHER affinity for dopa

Answer 6

buproprion

Question 7

antagonist at 5HT2/3 and H1

Answer 7

mirtazepine

Question 8

block sero and NE?

Answer 8

SNRIs

Question 9

block 5HT2a and 5HT1a at high doses

Answer 9

trazadone

Question 10

blocks 5HT2

Answer 10

nefazodone

Question 11

serotonin reuptake blockade, potent inhibitor of P450

Answer 11

SSRIs

Question 12

substitute for sodium

Answer 12

lithium

Question 13

blocks turnover and release of dopa and NE but INCREASED SEROTONIN

Answer 13

lithium

Question 14

depletes phosphatidylinositol-4,5 biphosphate (PIP2)

Answer 14

lithium

Question 15

reversibly inhibits nerve conduction .. binds and inhibits opening of sodium channels on INTRACELLULAR side

Answer 15

local anesth.

Question 16

prototype, competitive antagonist at nicotinic receptor

Answer 16

curarine

Question 17

prevents depolarization by Ach (hypotension from histamine release)

Answer 17

d-Tubocurarine

Question 18

laudanosine metabolite, histamine release

Answer 18

atracurium

Question 19

NO laudanosine, no histamine release, more potent

Answer 19

CISatracurium

Question 20

non depolarizing steroid that blocks muscarinic receptors (part of triple cocktail lethal injxn)

Answer 20

pancuronium

Question 21

non depolarizing steroid that has slight antimusc effects, for ppl w/ CV probs

Answer 21

rocuronium

Question 22

nicotinic agonist- fasiculations followed by desensitized

Answer 22

succinylcholine

Question 23

alpha 2 agonist, spasmolytic

Answer 23

tizanidine

Question 24

blocks ryanodine receptor in Ca release channels

Answer 24

dantrolene

Question 25

blocks Ach in NMJ

Answer 25

botox

Question 26

NET & SERT inhibitor, NMDA antagonist

Answer 26

methadone

Question 27

quick onset, short DOA, faster than morphine but slower than heroine, many options?

Answer 27

fentanyl (i.e. transmucosal for cancer pain)

Question 28

anticholinergic so NO BRADY or CONSTIPATION

Answer 28

meperidine

Question 29

prodrug that undergoes demethylation to become activated

Answer 29

codeine

Question 30

weak inhibitor of NET and SERT reuptake and u agonist

Answer 30

tramadol

Question 31

kappa agonist, mu antagonist

Answer 31

nalbuphine

Question 32

MU partial agonist, kappa antagonist

Answer 32

buprenorphine

Question 33

at higher doses also zero order kinetics

Answer 33

aspirin

Question 34

reduces prostaglandin formation, does NOT affect leukotrienes

Answer 34

aspirin

Question 35

TNF alpha and NO synthesis inhibitor

Answer 35

flubiprofen

Question 36

inhibits cyclooxygenase AND lipoxygenase activity

Answer 36

ketoprofen

Question 37

extremely potent- ONLY to reach a narcotic analgesic level

Answer 37

ketoprofen

Question 38

not good at inhibiting inflammation, mostly parenteral, almost as good as morphine

Answer 38

ketorolac

Question 39

only NON ACID NSAID, ketone prodrug

Answer 39

nabumetone

Question 40

pyrroleacetic acid

Answer 40

tolmetin

Question 41

binds to 5HT1B and 1D- agonists; cause vasoconstriction

Answer 41

triptans

Question 42

5HT1B and D agonists; antidote is nitroprusside

Answer 42

ergot alkaloids

Question 43

NONpurine xanthine oxidase inhibitor

Answer 43

febuxostat

Question 44

inhibits organic anion transporter so that you can’t reabsorb uric acid

Answer 44

probenecid

Question 45

inhibits nociceptor transmission in dorsal horn

Answer 45

tizanidine