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Pharmacology > PharmExam4- composition/MOA > Flashcards

PharmExam4- composition/MOA Flashcards

1
Q

active metabolite Nortriptiline

A

amtriptiline

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2
Q

most potent, selective inhibitor of NE reuptake

A

imipramine

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3
Q

most selective for inhibition of serotonin reuptake

A

clomipramine

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4
Q

unique: NO action on transporters; EXTREMELY strong affinity for histamine

A

trimipramine

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5
Q

D2 receptor antagonist; mixed antidepressant and neuroleptic

A

amoxapine

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6
Q

unique- binds NE but HIGHER affinity for dopa

A

buproprion

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7
Q

antagonist at 5HT2/3 and H1

A

mirtazepine

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8
Q

block sero and NE?

A

SNRIs

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9
Q

block 5HT2a and 5HT1a at high doses

A

trazadone

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10
Q

blocks 5HT2

A

nefazodone

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11
Q

serotonin reuptake blockade, potent inhibitor of P450

A

SSRIs

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12
Q

substitute for sodium

A

lithium

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13
Q

blocks turnover and release of dopa and NE but INCREASED SEROTONIN

A

lithium

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14
Q

depletes phosphatidylinositol-4,5 biphosphate (PIP2)

A

lithium

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15
Q

reversibly inhibits nerve conduction .. binds and inhibits opening of sodium channels on INTRACELLULAR side

A

local anesth.

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16
Q

prototype, competitive antagonist at nicotinic receptor

A

curarine

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17
Q

prevents depolarization by Ach (hypotension from histamine release)

A

d-Tubocurarine

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18
Q

laudanosine metabolite, histamine release

A

atracurium

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19
Q

NO laudanosine, no histamine release, more potent

A

CISatracurium

20
Q

non depolarizing steroid that blocks muscarinic receptors (part of triple cocktail lethal injxn)

A

pancuronium

21
Q

non depolarizing steroid that has slight antimusc effects, for ppl w/ CV probs

A

rocuronium

22
Q

nicotinic agonist- fasiculations followed by desensitized

A

succinylcholine

23
Q

alpha 2 agonist, spasmolytic

A

tizanidine

24
Q

blocks ryanodine receptor in Ca release channels

A

dantrolene

25
Q

blocks Ach in NMJ

A

botox

26
Q

NET & SERT inhibitor, NMDA antagonist

A

methadone

27
Q

quick onset, short DOA, faster than morphine but slower than heroine, many options?

A

fentanyl (i.e. transmucosal for cancer pain)

28
Q

anticholinergic so NO BRADY or CONSTIPATION

A

meperidine

29
Q

prodrug that undergoes demethylation to become activated

A

codeine

30
Q

weak inhibitor of NET and SERT reuptake and u agonist

A

tramadol

31
Q

kappa agonist, mu antagonist

A

nalbuphine

32
Q

MU partial agonist, kappa antagonist

A

buprenorphine

33
Q

at higher doses also zero order kinetics

A

aspirin

34
Q

reduces prostaglandin formation, does NOT affect leukotrienes

A

aspirin

35
Q

TNF alpha and NO synthesis inhibitor

A

flubiprofen

36
Q

inhibits cyclooxygenase AND lipoxygenase activity

A

ketoprofen

37
Q

extremely potent- ONLY to reach a narcotic analgesic level

A

ketoprofen

38
Q

not good at inhibiting inflammation, mostly parenteral, almost as good as morphine

A

ketorolac

39
Q

only NON ACID NSAID, ketone prodrug

A

nabumetone

40
Q

pyrroleacetic acid

A

tolmetin

41
Q

binds to 5HT1B and 1D- agonists; cause vasoconstriction

A

triptans

42
Q

5HT1B and D agonists; antidote is nitroprusside

A

ergot alkaloids

43
Q

NONpurine xanthine oxidase inhibitor

A

febuxostat

44
Q

inhibits organic anion transporter so that you can’t reabsorb uric acid

A

probenecid

45
Q

inhibits nociceptor transmission in dorsal horn

A

tizanidine

Pharmacology (21 decks)

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