Pharm2Anti-Myco/Fung

Question 1

inhibits syn and assembly of mycolic acids into outer layer of mycobac by inhibiting?
toxicity? correct w/?
most serious s/e?

Answer 1

isoniazid (syn derivative of B6)
fatty synthetase II
peripheral neuritis, B6
fatal hepatitis

Question 2

inhibits RNA synthesis (TRANSCRIPTION!)
effect on P450?
if pt taking protease inh, give ?

Answer 2

rifampin
induces!- increased metabolism
rifabutin
*can stain contacts!!

Question 3

1st line TB, (RIPE), enters csf- TB meningitis?

Answer 3

pyrazinamide- bacteriocidal

Question 4

1st line; Tx MAI complex?

s/e ?

Answer 4

ethambutol- bacteriostatic

optic neuritis- decreased VA & color vision disturbances

Question 5

2nd line tb that enters CSF, similar to isoniazid?

Answer 5

ethionamide

Question 6

2nd line tb like a/g, inhibits protein syn, nephro/ototoxicity

Answer 6

capreomycin

Question 7

2nd line tb that inhibits bacterial cw sun & enters CSF

Answer 7

cycloserine (CNS s/e)

Question 8

RDC for leprosy

• inhibits folate biosyn? (sulf. derivative); also Tx PCP
• inhibits DNA fxn & rep, also Tx ?
• bacteriocidal?
• static?

Answer 8

dapsone
clofazimine, MAI complex
cidal- rifampin, dapsone
static- clofzimine

Question 9

s/e methemoglobinemia, erythema nodosum?

Answer 9

dapsone

Question 10

s/e red-brown skin discoloration, eosinophilic enteritis

Answer 10

clofazimine

Question 11

amphotericin B

• SOA?
• given ? only
• can only enter csf w/ ? for cryptoococcus men.
• give ? by itself for ? do to coccidiodes

Answer 11

tx all 7 fungal infx, 1st line for life-threatening
IV
flucytosine
intrathecally**, fungal meningitis

Question 12

tx chromoblastomycosis?

Answer 12

flucytosine

Question 13

give PO & inhibits DNA & RNA sun by blocking thymidylate synthase?

Answer 13

flucytosine

Question 14

1st line for candidemia, mucosal candidiasis, coccidiomycosis
given ORALLY for ??
prophy ? in AIDS pts

Answer 14

fluconazole
fungal meningitis***
cryptococcal meningitis

Question 15

DOC/1st line for paracoccidiodomycoses, histoplasmosis, blastomycosis; NO CSF
s/e ??

Answer 15

itraconazole

minerlcorticoid-like s/e

Question 16

first line for aspergillosis, PO or IV

Answer 16

voriconazole; s/e V for visual disturbances

Question 17

first line for prophy aspergillus and candida in I/C

Answer 17

posaconazole

Question 18

echinocandins - 'fungin-
MOA?
MUST be given ? 
prophy candida in BM transplant?
aspergillus salvage tx?
main s/e?
toxicity?

Answer 18

inhibit cell wall by inh B-glucan synthase
IV
micafungin
caspofungin
myelosuppression
vancomycin-like

Question 19

inhibits microtubule assembly?
effective against dermatophytes, PO
distributes to ?
? diet promotes absorption

Answer 19

griseofulvin
hair, skin, nails
high-fat

Question 20

also effective against tine, PO and topical, inhibits erg synthesis?

Answer 20

terbinafine

Question 21

same MOA as amp B? (2)

Answer 21

nystatin, natamycin

Question 22

like amph B, nystatin not ? when given orally

Answer 22

absorbed

Question 23

ophthalmic antifungal suspension for fungal keratitis, blepharitis, conjunctivitis?

Answer 23

natamycin

Question 24

all azoles (INCLUDE TOLNAFTATE) inhibit ? and have ?

Answer 24

erg syn, drug int

Question 25

s/e in all anti-fungals?

Answer 25

hepatic dysfxn

Question 26

don’t use keto w/ ?

Answer 26

amph B- will inn its effects like a static antagonizing a cidal

Question 27

for candida use ? w/ keto

Answer 27

flucytosine

Question 28

remaining -azoles are only ?

Answer 28

topical (bc of toxicity)