Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Pharm2Anti-Viral/Protozoa > Flashcards

Pharm2Anti-Viral/Protozoa Flashcards

1
Q

inhibit viral neuraminidase and block viral rep?

A

Oseltamivir- PO & Zanamivir- inhalation
both CI in neonates
zanmivir CI in COPD & asthma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

inhibits viral mRNA syn/transcription
virazole given by inhalation for serious RSV infix
CI in ?

A

ribavirin

pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

monoclonal ab against RSV- prophy in high risk peds pts for LRT Dz

A

palivizumab - IM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

DOC for HSV encephalitis, zoster?

also tx HSV 1,2, labialis, CMV prophy

A

acyclovir- PO/IV!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ORAL for genital herpes, herpes labialis, zoster

A

valacyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

HSV keratitis & keratoconjunctivitis

A

trifluridine aka virOPTIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

topical tx of herpes labialis

A

penciclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

prodrug of pen; ORALLY for zoster

A

famciclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Docosanol?

A

OTC for herpes labialis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

TREATS CMV retinitis and CMV prophy

s/e- myelosuppression

A

ganciclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

IV for CMV retinitis?

A 
cidofovir 
foscarnet (only one not phosphorylated- pyrophosphate derivative)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

foscarnet s/e?

A

electrolyte disturbances- hypoCa&K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

NRTIs MOA similar to ?

  • nucleosides phophorylated into ? by ? in the virus and then in the host
  • only activated in cells infected with virus
  • converted into ? in cells and inhibit ?
  • s/e? (3)
A

acyclovir
nucleotides, protein kinases
triphosphate, RT
myelosuppression, peripheral neuropathies, hepatomegaly w/ steatosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

directly & non competitively inhibit RT by disrupting RT catalytic site? (aren’t nucleosides so DONT need to be activated)

A

NNRTIs

neVIRapine, delaVIRdine, efaVIRenz, etraVIRine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

w/ fusion inh (enfuviritide- sQ), increased risk of ?

bind to viral envelop glycoprotein and prevent HIV from entering ?

A

pneumonia

WBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

for Hep B virus?

if resistant?

A

lamivudine (epivir, epivir-HBV)

adefovir, entacavir

17
Q

NRTI that converts AZT to AZT triphosphate & inhibits DNA syn via inh RT
»>crosses BBB***
»>s/e worst ? of all NRTIs

A

zidovudine

bone marrow toxicity

18
Q

didanosine & lamivudine s/e?

A

pancreatitis

19
Q

zidovudine & lamivudine called ?

A

combivir

20
Q

inhibit cleavage of polypeptide precursors that generate proteins/enzymes- block rep
-commonly used with ?

A

protease inh

zidovudine, lamivudine

21
Q

interferes w/ parasites microtubule fxn, inhibiting glucose uptake; tx ALL 7 nematodes

A

albendazole

22
Q

inh depolarization- activation of nicotinic receptors-paralysis; pinworm/roundworm/hookworm

A

pyrantel pamoate

23
Q

activates GABA receptors (inhibitory)- paralysis
-DOC for ?
also treats? (2)

A

ivermectin
onchocerciasis
filariasis, head lice (SKLICE)

24
Q

Trematodes & cestodes tx by?

A

praziquantel

25
Q

treats blood and liver fluke by increasing ca permeability- paralysis of worm

A

trematodes- praziquantel

26
Q

tx taenia saginata/solium, cysticercosis but ? is DOC and CANT tx ocular bc paralysis of worm in eye may lead to blindness!

A

cestodes- praziquantel

albendazole

27
Q

mixed amebicide, accepts electrons leading to cytotoxic free radicals
-DOC for E histolytica, giardia, bac vaginosis; also tx anaerobic infx i.e. c diff, bacteroides

A

metronidazole (crosses BBB- meningitis)

28
Q

luminal amebicides?

systemic?

A

parmomycin, iodoquinol

chloroquine- amebic liver abscess

29
Q

radical cure for milaria, tissue schizonticide that eradicates 1 and 2 EXOerythrocytic form of P vivax and ovale

A

primaquine; s/e: hemolytic anemia

30
Q

BLOOD schizonticide that only eradicates erythrocytic form; CLINICAL cure (alleviates Sx)
-s/e (2)?

A

chloroquine
in combo w/ metro and iodoquinol for prophy/tx of amebic liver abscess
visual disturbances, ototoxicity

31
Q

used for chloroquine-resistant malarial strains?

s/e?

A

quinine

cinchonism

32
Q

blood schizonticide for MDR P. falciparum malaria

A

mefloquine; s/e- hallucinations

33
Q

blood schizonticide- folate antagonist

P falciparum, P malariae, Toxoplasma gondii

A

pyrimethamine

34
Q

blood AND tissue schizonticide
Atovaquone & Proguanil
syn inn of pyrimidine biosynthesis in malaria
prophy and tx of MDR strains (chloroquine AND quinine)

A

MALarone

35
Q

trypanosomiasis- brucei gambiense/rhodiense

  • only to cross BBB?
  • tx and prophy; also tx and prophy for PCP?
  • cytotoxic radicals; only one for Chagas’ (cruzi)?
  • prophy and early tx; also tx onchocerciasis?
A

melarsoprol- IV
pentamidine isethionate- aerosol or IM
nifurtimox- PO
suramin- IV, a/e: shock

36
Q

sodium stibogluconate for ?

A

leishmaniasis; s/e: cardiac arrhythmias

37
Q

amebicide that induces cell membrane leakage?

A

paromomycin

38
Q

s/e of blood schizonticide and sporontocide - megaloblastic anemia - reverse w/ leucovorin ?

A

pyrimethamine

Pharmacology (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions