Pharm2CWI

Question 1

carbapenems

empiric tx - 2

Answer 1

imipenem

meropenem

Question 2

carbapenems resistant to most?

Answer 2

beta lactamases

Question 3

penem that tx various nosocomial infx from serrate, actinobacter?

Answer 3

imipenem (w/ cilastatin b/c it is hydrolyzed by renal dehydropeptidase to nephrotoxic metabolite)

Question 4

penem that may cause seizures?

Answer 4

imipenem (broadest b lactam on market)

Question 5

monobactam name?
resistant to?
no ? activity, only ?
UTIs, RTIs, nosocomial

Answer 5

Aztreonam
b-lactamases
G + activity, G - aerobic

Question 6

Bacitracin - CWI
SOA?
topical ONLY, systemic can lead to ?
skin, ocular w/ ?

Answer 6

gram pos
nephrotoxicity
neomycin, polymixin B

Question 7

vancomycin
SOA?
w/ ? for synergism
DOC/1st line for ? (3)
*only oral for c diff; rest are slow IV b/c of flushing, shock, etc.; can also have ??

Answer 7

Gram pos
a/g
tetanus, pen-resistant s. pneumo, MRSA
ototoxicity

Question 8

gramcidin- membrane disruptor 
only TOPICAL
SOA?
s/e?
replaces bacitracin in combo with ? and ? for ocular infix?

Answer 8

G + cocci, bacilli
hemolysis
polymixin B, neosporin

Question 9

daptomycin- depolarizes membrane potential
SOA?
is considered a cyclic ?
MDRSP VRSA MRSA VRE endocarditis bacteremia

Answer 9

only G+

lipopeptide

Question 10

fosfomycin- PO
SINGLE dose to treat?
safe & used in ?
resistance from?
commonly UTI in female

Answer 10

acute cystitis
PREGNANCY***
decreased permeability

Question 11

2nd line TB; bacterioSTATIC

s/e: ? toxicity, ? neuropathies

Answer 11

Cycloserine

CNS- CROSSES BBB, peripheral

Question 12

Polymixin B- bacteriocidal for ?
usually topical, opthalmic
? ? and ? are resistant
s/e- nephro/neurotoxicity
Tx ? corneal ulcers and external otitis media
cationic detergents

Answer 12

G neg rods only!
G+, proteus, neisseria
pseudomonal