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Pharmacology > Pharm2- CNS NT > Flashcards

Pharm2- CNS NT Flashcards

1
Q

selective antagonist & potent convulsant of glycine

A

strychnine

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2
Q

musc receptors

  • bind to IP3/DAG?
  • bind to Gi?
A

M1/3/5

M2/4

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3
Q

D2 autoreceptor will ? and ?

A

inhibit dopa syn AND release

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4
Q

in the locus ceruleus & lateral segmental system?

A

NE

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5
Q

NE
excitatory?
inhibitory?

A

a1, b1

a2, b2, b3

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6
Q

serotonin mostly inhibitory in the CNS by ?

A

increasing K conductance

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7
Q

serotonin

all rec are GPCR’s except ? is a ?

A

5HT3, cation channel

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8
Q

block 5HT transporter (4)

A

ecstasy
cocaine
SSRIs
TCAs

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9
Q

MAO a/b degrades?

COMT?

A

NE, DA, 5HT

NE, DA

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10
Q

histamine rec
excite?
inhibit?

A

H1/2

H3

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11
Q

excitatory rec on ALL neurons?

A

AMPA

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12
Q

ligand binding and channel closed is termed?

i.e. glutamate will not bind when present in body

A

desensitization

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13
Q

coagonist receptor glutamate/glycine can’t open unless ?

A

Mg comes out/is pushed out of the way

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14
Q

the Mg will only fly out if the cell is ? and will open the NMDA receptor channel completely

A

depolarized

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15
Q

glutamate long term potentiation (LTP) involved in ? and ?

A

learning, memory

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16
Q

inhibit glutamate release, treat seizures?

A

lamotrigine

17
Q

antagonist at glycine allosteric site of NMDA to treat seizures?

A

felbamate

18
Q

inhibit transmission in s.c. and brainstem

A

glycine

19
Q

rate limiting step in synthesis of dopa>NE>Epi?

A

tyrosine hydroxylase (converts l-tyrosine to l-dihydroxyphenylalanine

20
Q

2 substances not stored?

A

endocannabinoids

nitrous oxide

21
Q

synthesized from L-arginine; DIRECTLY interacts w/ 2nd messenger system?

A

nitrous oxide

22
Q

major excitatory?

A

glutamate

23
Q

major inhibitory? yeng to glutamate-ying?

A

GABA

24
Q

memory, sensory, motor, coordination, NMJ, ANS/PANS

A

Ach

25
Q

sleep, sedation, and TEMP REGULATION

A

histamine

26
Q

motor reg, reinforcement, OLFACTION*, mood, concentration, hormone control

A

dopamine

27
Q

CNS sensory processing, cerebellar fxn, sleep, mood, learning, memory, anxiety

A

NE

28
Q

emotional processing, mood, appetite, sleep, pain, hallucinations, reflex

A

serotonin

29
Q

ANY/ALL addictions: a ton of dopamine dumped into?

A

nucleus accumbens (also goes into neocortex into higher learning center)

30
Q

all serotonin receptors are ? except 5HT3, which is ?

A

modulatory, excitatory

31
Q

w/ nitric oxide, there is no?

A

receptor

32
Q

endocannabinoids are not ? and they move in a ? fashion

A

stored, retrograde (released from postsynaptic and bind to CB1 on presynaptic)

Pharmacology (21 decks)

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