Pharm2- CNS NT Flashcards
selective antagonist & potent convulsant of glycine
strychnine
musc receptors
- bind to IP3/DAG?
- bind to Gi?
M1/3/5
M2/4
D2 autoreceptor will ? and ?
inhibit dopa syn AND release
in the locus ceruleus & lateral segmental system?
NE
NE
excitatory?
inhibitory?
a1, b1
a2, b2, b3
serotonin mostly inhibitory in the CNS by ?
increasing K conductance
serotonin
all rec are GPCR’s except ? is a ?
5HT3, cation channel
block 5HT transporter (4)
ecstasy
cocaine
SSRIs
TCAs
MAO a/b degrades?
COMT?
NE, DA, 5HT
NE, DA
histamine rec
excite?
inhibit?
H1/2
H3
excitatory rec on ALL neurons?
AMPA
ligand binding and channel closed is termed?
i.e. glutamate will not bind when present in body
desensitization
coagonist receptor glutamate/glycine can’t open unless ?
Mg comes out/is pushed out of the way
the Mg will only fly out if the cell is ? and will open the NMDA receptor channel completely
depolarized
glutamate long term potentiation (LTP) involved in ? and ?
learning, memory
inhibit glutamate release, treat seizures?
lamotrigine
antagonist at glycine allosteric site of NMDA to treat seizures?
felbamate
inhibit transmission in s.c. and brainstem
glycine
rate limiting step in synthesis of dopa>NE>Epi?
tyrosine hydroxylase (converts l-tyrosine to l-dihydroxyphenylalanine
2 substances not stored?
endocannabinoids
nitrous oxide
synthesized from L-arginine; DIRECTLY interacts w/ 2nd messenger system?
nitrous oxide
major excitatory?
glutamate
major inhibitory? yeng to glutamate-ying?
GABA
memory, sensory, motor, coordination, NMJ, ANS/PANS
Ach
sleep, sedation, and TEMP REGULATION
histamine
motor reg, reinforcement, OLFACTION*, mood, concentration, hormone control
dopamine
CNS sensory processing, cerebellar fxn, sleep, mood, learning, memory, anxiety
NE
emotional processing, mood, appetite, sleep, pain, hallucinations, reflex
serotonin
ANY/ALL addictions: a ton of dopamine dumped into?
nucleus accumbens (also goes into neocortex into higher learning center)
all serotonin receptors are ? except 5HT3, which is ?
modulatory, excitatory
w/ nitric oxide, there is no?
receptor
endocannabinoids are not ? and they move in a ? fashion
stored, retrograde (released from postsynaptic and bind to CB1 on presynaptic)
