Pharm2 PD/Antipsychotics

Question 1

dopamine replacement- ? if used w/ MAOI

Answer 1

hypertensive crisis

Question 2

w/ PD- don’t use ? antiemetic (blocks D2)

Answer 2

phenothiazine

Question 3

sQ for extended off periods late in dz?

Answer 3

apomorphine- dopa agonist

Question 4

don’t use meperidine w/ seleGLINE or rasaGLINE» ?

Answer 4

serotonin syndrome

Question 5

peripherally reduces amount of 3-O-methyldopa formation and reduces DA breakdown in brain
-tolcapone vs etacapone?

Answer 5

COMT inhibitors

CNS and PNS, monitor LFTs

Question 6

etacapone + carbadopa + levodopa

Answer 6

stalevo

Question 7

antimusc for PD

s/e and CI?

Answer 7

hallucinations, dementia

Question 8

Huntingtons tx:
chorea- dec dopamine (2), block DA rec (2)
psych effects- antidep? anti psych?

Answer 8

reserpine (more s/e), tetrabenazine (blocks dopa vesicular transport)
phenothizines, haloperidol
fluoxetine, clozapine

Question 9

D1 antagonist along w/ D2 DOPA AGONIST for PD?

Answer 9

bromocriptine

Question 10

quantitative atypical?

Answer 10

risperidone

Question 11

symbyax- ?&? for ?

Answer 11

olanzapine&fluoxetine, depression

Question 12

neuroleptic malignant syndrome - excessive dopamine inhibition caused by?
tx w/?

Answer 12

haloperidol
DA agonist- bromo and l-dopa if necessary
m relaxants- diazepam, DANTROLENE

Question 13

low seizure threshold, also block H1 rec (sedation)?

Answer 13

chlorpromazine, clozapine

Question 14

treat tardive dyskinesia w/?

Answer 14

TCAs, benzos

Question 15

tx acute dystonia w/?

Answer 15

cogentin

Question 16

antipsych diff mech: partial agonist at D2 and 5HT1a; antagonist at 5HT2a***

Answer 16

apiprazole (abilify)