Pharm2- Ethanol/DrugsofAbuse

Question 1

? is required for activity of alc dehydrogenase?

Answer 1

NAD

Question 2

rate limiting step?

Answer 2

NAD+&raquo_space;> NADH

Question 3

chief cause of met d/o in alc?

Answer 3

excess of NADH in liver

Question 4

asian gene mutation

same actions as disulfiram- increase in ? due to ?

Answer 4

ALDH, low affinity for NAD+

Question 5

w/ large qty of alc- another p/w becomes available? produces ? & ? w/ drugs

Answer 5

MEOS (microsomal ethanol oxidizing system), free radicals, cross tol/interactions

Question 6

ethanol actions
inc GABA, opioids
dec ? and ?

Answer 6

NMDA rec fxn- blackouts, Ca influx

Question 7

hepatic changes?

sexual?

Answer 7

none ACUTE

hyperestroginization in males (dec. test)

Question 8

prevents alc-related seizures?

Answer 8

lorazepam

Question 9

48-72h post drinking- autonomic instability, disorientation, and ? called?

Answer 9

hallucinations

deilirium tremens

Question 10

? can return liver with high trigly and inc NADH to normal

Answer 10

high cal diet

Question 11

alc inc risk of pulm dz - ? and ?

Answer 11

ARDS, pneumonia

Question 12

short term tx, can dec consumption in heavy drinkers, opioid ant at U rec?

Answer 12

naltrexone

Question 13

GABAb agoniest that dec cravings in alc?

Answer 13

baclofen

Question 14

MC benzos for alc w/drawal?

Answer 14

diazepam

chlordiazepoxide

Question 15

a/e of methanol poisoning?

Answer 15

severe acidosis

retinal damage/blindness

Question 16

blocks DAT and NET?

Answer 16

cocaine

Question 17

REVERSES action of DAT and NET? also bind to VMAT

Answer 17

amphetamines

Question 18

dental probs, bruxism?

Answer 18

amphetamines

Question 19

meth vs. cocaine (3)

Answer 19

man made
longer high
increases release AND blocks uptake

Question 20

cold turkey, kicking the habit?

Answer 20

opioid s/e

Question 21

very long half life, gradual onset, opioid tx?

Answer 21

methadone

Question 22

opiod tx:
PARTIAL agonist at mu and nociceptin
ANTAGONIST at kappa

Answer 22

bupenORPHINE

Question 23

opioid antagonist at u rec; no euphoria- poor compliance

Answer 23

naltrexone

Question 24

dissociative; noncompetitive NMDA antagonists?

Answer 24

ketamine, PCP

Question 25

NMDA antagonist and sigmoid rec agonist?

Answer 25

PCP

Question 26

inactogenic, ALL serotonin related?
prevents reuptake and reverses SERT actions via phosphorylation
-binds to ?
-toxic: ?, ?

Answer 26

MDMA - ecstasy
5HT1
dehydration (hyponatremia), hyperthermia

Question 27

no addiction but rapid tolerance ?

main target?

Answer 27

hallucinogens

5HT2a

Question 28

halluc- bind at 5HT1a also, intense emotional swings, HPPD- flashbacks, abortion-inducing?

Answer 28

LSD

Question 29

spineless cactus- mescaline?

Answer 29

peyote; can have fetal abn

Question 30

mushrooms; tea or foods, 6 h, relaxation, weakness, ataxia, pupil dilation, N/V

Answer 30

psilocybin

Question 31

THC causes disinhibition of ?

Answer 31

dopa neurons

Question 32

weed tx? 3

Answer 32

decreases IOP, inc appetite for chemo, neuropathic pain

Question 33

NABIlone, droNABInol tx?

Answer 33

AIDS, N/V in chemo, fibromyalgia (nabilone)

Question 34

MAOI that inc DA/NE/5-HT; release Epi and glucose; dec insulin output?

Answer 34

tobacco

Question 35

tobacco tx:

• dopa & NE reuptake inh?
• nicotine rec agonist on dopa neuron in VTA; stim rec w/o release of dopa; impaired driving and increased suicide ideation

Answer 35

buproprion

varenicline