Pharm2Spectrum/PCN

Question 1

probenecid blocks tubular secretion/prolongs activity of ?

Answer 1

PCN, cephs

Question 2

? and ? are resistant to cephs

Answer 2

listeria, c. diff

Question 3

used synergistically with a/g (gentamicin)?

Answer 3

PCN, cephs

Question 4

ceph- G1?

Answer 4

G + cocci, PEcK

Question 5

ceph- G2?

subclass?

Answer 5

G + cocci, PEcK HiM

anaerobes (B. fragilis, C. perfringens)

Question 6

ceph- G3?

Answer 6

G + cocci, PEcK HiM &

Neisseria g., Serratia, Citrobacter, Providencia

Question 7

ceph- G4?

Answer 7

similar to G3 but better for Enterobacter

P. aeroginosa

Question 8

ceph- G5?

Answer 8

similar to G2 plus Enterobacter&Citrobacter

MRSA, VRSA, VISA, VREF (enterococcus faecalis)

Question 9

carbapenems
most ? beta lactams
resistant to most?

Answer 9

broad

beta lactamases

Question 10

bacitracin spectrum of activity?

Answer 10

G + cocci and bacilli

Question 11

vancomycin?

Answer 11

G + only

Question 12

aztreonam (monobactam)
esp?
NO?

Answer 12

G - bacilli

G + *****

Question 13

polymixin B bacteriocidal for ?

Answer 13

gram - bacilli (no G + activity)

Question 14

sulfonamides bacteriostatic against ?

Answer 14

G + & -

Question 15

FQ- G2?

Answer 15

G - activity

Question 16

FQ- G3 & 4?

Answer 16

G - AND + (b/c of iso IV)

Question 17

TCN- broadest spectrum Abx! ….

Answer 17

aerobic AND anaerobic G- and G+

Question 18

A/G ?

Answer 18

severe infix from G- bacilli

Question 19

FQ - resistance?

Answer 19

Beta lactamases

Question 20

macrolides do not ? aka can’t tx?

Answer 20

BBB, meningitis

Question 21

macrocodes are ?/? in low concentrations BUT ?/? in high !

Answer 21

bacteriostatic/P.O.

bacteriocidal/IV

Question 22

? is resistant to all macrolides

Tx with?

Answer 22

strep pneumo

telithromycin

Question 23

drug interactions (4)

Answer 23

erythro
clarithro
chloramphenicol
all of the -azoles

Question 24

amino glycosides are synergistic with all ? and ?

Answer 24

beta lactams, vancomycin

Question 25

amphotericin b w/ ? for ?

Answer 25

fluconazole, coccidiodomycosis meningitis

Question 26

Pen G activity

Answer 26

gram pos: cocci, meningococci, bacilli, anaerobes spirochetes (DOC chlam, lymes) little gram neg activity

Question 27

Pen V activity more stable than ? Tx ? infx, streptococci, ? pneumococci

Answer 27

Pen G | oropharyngeal, pcn-SENSITIVE

Question 28

extended spectrum PCNs

Answer 28

pen G & gram neg (HEMP) H flu, E coli, Morax, Proteus

Question 29

Ticercillin & piperacillin- only pcn? | otherwise same as amos

Answer 29

active against pseudomonas, klebsiella, bacteroides

Question 30

MRSA develops from resistance via? | so does ? and ?

Answer 30

modification of PBPs | pen-resistant pneumococci, enterococci

Question 31

beta lacatamase inhibitors are added to drugs to be able to treat ?

Answer 31

penicillinase producing organisms

Question 32

food decreases absorption in all PCN except?

Answer 32

amox

Question 33

Weil's Dz (?) and Actinomycosis are tx by?

Answer 33

(leptospira) Pen G

Question 34

? also treat salmonella, shigella, campylobacter

Answer 34

ampicillin (gastroenteritis)

Question 35

Amox good for ? but bad for ? bc 90% gets absorbed | Ampicillin 1st line for ? and good for ? b/c 50% gets absorbed

Answer 35

H pylori, GI tract infxn Listeria meningitis (G+ meningitis!), Gastroenteritis

Question 36

make beta lactamase (2)

Answer 36

staphylococcus | enterobacter

Question 37

make penicillinase (6) steph klub makes HEMP! (formerly

Answer 37

``` staph kleb haemophilus e coli moraxella pasteurella ```