Pharm2Sulf/FQ Flashcards
sulf:
SOA:
s/e: ?uria, hypersensitivity, ? in newborns, drug potentiation from ?
G+&-
crystal, kernicterus, albumin displacement
aka pediazole; otitis media (H flu) in peds
erythro (ESP) & sulfasoxazole
UTIs, RTIs, gastroenteritis, PCP***
sulfamethoxazole-trimethroprim
toxoplasmosis; give w/
sulfadiazine & pyramethamine; folinic acid
broken down to 5-aminosalicylate; Tx IBD?
sulfasalazine (PO or suppository)
topical for eye and skin infx, acne
sulfacetamide
Tx burns, prevent sepsis
silver sulfadiazine
- much more potent than sulfa’s, analog of dihydrofolic acid; UTIs & bacterial prostatitis?
- inhibits ? (second step in FA sun
- s/e?; reverse w/?
trimethroprim
dihydrofolate reductase
granulocytopenia, leukopenia, megaloblastic anemia; folinic acid
- 1st line haem (otitis, sinusitis, pneumonia, chancroid), moraxella (same but not chancroid), enterobacter»> think RTIS in ?
- Tx gastroenteritis (salmonella, shigella)
- DOC for ?
- OK in ???
SMX-TMP aka cotrimoxazole, PEDS
nocardiosis, PCP
CHILDREN
FQ will treat IC bc it accumulates in ? and ?
macrophages, PMNs
FQ resistance: (2)
altered target site
decreased accumulation
-Tx UTIs, prostatitis (E coli, enterobacter); FQ w/ most clinical apps;
primarily gram ned aerobes
-pseudomonas associated with ?
-also shigella, salmonella, campylobacter, vibrio
cipro
cystic fibrosis
best bioavailability, best FQ for chlamydia trachomatis urethritis?
ofloxacin
most commonly Rx’ed FQ?
G+ activity against? (4)
levo
staph a., s pneumo, strept pyo, MDRSP
FQ- Tx only bronchitis and pneum (aka RTIs)
gemifloxacin
