Pharm2TCN/Macrolides/A/G Flashcards
TCNs primarily for infix that can’t be tx with ?
B lactams
tcn 1st line for helicobacter?
tetra, also tx acne
tigecycline can tx ? which is ?
MDR gram pos cocci, bac resistant to TCN
also Tx MRSA, VRSA, VRE, bacteroides
TCN resistance via?
efflux pump
tcn forms ? with cations so oral absorptions is decreased with ingestion of ? and ?
chelates
dairy foods, antacids (Ca, Mg, Al, Fe)
TCN- CI in?
- s/e ?
- expired/outdated drugs?
pregnancy, breastfeeding, children <8
GI, phototoxicity, esophageal ulcers
Fanconi syndrome
TCN
SOA:
G- aerobes, G- and + anaerobes» BROADEST
DOES NOT Tx G+ aerobes but tigecycline will!!
Mino eradicates ? and Tx? (2)
-concentrates in ?
N. meningitis (carrier), Nocardia, acne
-tears & saliva
general s/e of tcn?
fetal teeth discoloration, bone formation
macrolide- Pen G sub in allergy?
erythro
1st line for chanchroid & diphtheria?
erythro
clarithro- more ? activity; 1st line for ?
IC activity, MAI complex
azithro- more activity against ? and ?
H&M; haemophilus, moraxella
macrolides safe in?
pregnancy, children
macrolides do not tx?
meningitis (don’t cross BBB)
macrolide resistance:
G+?
G-?
altered target site
inactivated by plasmid-associated esterase
ALL macrolides tx?
ALL are 1st line for?
pen-resistant S. pyogenes
diphtheria
clarithromycin ? w/ food
increases absorption (erythro & azithro opposite)
1st line for MAI, chlamydia pneum, diphtheria?
clarithro
DOC - 1 dose for trachomatis
1st line diphtheria, legionnaires
azithro
strept pneum resistant to ALL macrolides- Tx w/ ?
telithromycin (ketolide)
telithro binds to ?
2 sites on 50s
telithro:
only tx ? bc of liver damage
s/e?
CI?
CAP (resistant to macrolides)
jaundice, PROLONGED QT
<18
a/g are bacterioCIDAL b/c they ?
inhibit protein synthesis IRREVERSIBLY
a/g
SOA: all ? but NO ANAEROBES
limited G+ activity
gram neg bacilli
a/g can tx ? when given w/ CWI!
meningitis (a/g don’t cross BBB)
DOC for plague, tularemia
streptomycin
w/ yersinia aka black death/plague- +/-TCN
a/g- gentamicin = exception bc?
>DOC for ? and ? from ? in combo w/
>infx assoc w/ ?
>also first line for MENINGITIS and bacteremia from ? or ? and can be employed with ? or ?
- tx gram pos!
- bacteremia, endocarditis; enterococcus; ampicillin, pen G, vancomycin
- burns
- strep agalactiae, listeria; penG, ampicillin
tx brucella ?
genta & doxy
1st line for bacteremia & pneum & UTIs due to pseudomonas?
tobramycin
broadest spectrum a/g
resistant to inactivating enzymes
tx nosocomial infx i.e. enterobacter, serratia that are resistant to ? and ?
amikacin
genta, tobra
? give orally for bowel sterilization & surgical prophy for hepatic coma
s/e?
neomycin
NM paralysis
only for severe infix
back up for rickettsia and psitticosis
chloramphenicol
prophy endo w/ pcn allergy
clindamycin
fusobacterium givngivitis?
clindamycin
clindamycin does NOT treat ?»_space;narrow spectrum even though it treats ?
a/e?
concentrates in?
G- aerobes
G+ aerobes, G+ and - anaerobes
pseudo. colitis
bone! (like cefazolin)
inhibits bacterial isoleucyl transfer-RNA synthase?
Bacteriocidal, Tx skin lesions and ? (G+cocci)
eradication of ? in health care workers
mupirocin
impetigo (topical)
MRSA (intranasally)
related to a/g, bind to 30s, 3rd line treatment of gonorrhea
spectinomycin
interacts w/ 23s rRNA and inh 50s?
SOA?
linezolid (zyvox)
G+ cocci, includes pneumonia & Ent. facials
streptogramin-synercid
doesn’t treat?
only E. faecium
toxicity?
pneum
infusion phlebitis
