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Pharmacology > Pharm2TCN/Macrolides/A/G > Flashcards

Pharm2TCN/Macrolides/A/G Flashcards

1
Q

TCNs primarily for infix that can’t be tx with ?

A

B lactams

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2
Q

tcn 1st line for helicobacter?

A

tetra, also tx acne

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3
Q

tigecycline can tx ? which is ?

A

MDR gram pos cocci, bac resistant to TCN

also Tx MRSA, VRSA, VRE, bacteroides

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4
Q

TCN resistance via?

A

efflux pump

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5
Q

tcn forms ? with cations so oral absorptions is decreased with ingestion of ? and ?

A

chelates

dairy foods, antacids (Ca, Mg, Al, Fe)

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6
Q

TCN- CI in?

  • s/e ?
  • expired/outdated drugs?
A

pregnancy, breastfeeding, children <8
GI, phototoxicity, esophageal ulcers
Fanconi syndrome

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7
Q

TCN

SOA:

A

G- aerobes, G- and + anaerobes» BROADEST

DOES NOT Tx G+ aerobes but tigecycline will!!

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8
Q

Mino eradicates ? and Tx? (2)

-concentrates in ?

A

N. meningitis (carrier), Nocardia, acne

-tears & saliva

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9
Q

general s/e of tcn?

A

fetal teeth discoloration, bone formation

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10
Q

macrolide- Pen G sub in allergy?

A

erythro

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11
Q

1st line for chanchroid & diphtheria?

A

erythro

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12
Q

clarithro- more ? activity; 1st line for ?

A

IC activity, MAI complex

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13
Q

azithro- more activity against ? and ?

A

H&M; haemophilus, moraxella

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14
Q

macrolides safe in?

A

pregnancy, children

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15
Q

macrolides do not tx?

A

meningitis (don’t cross BBB)

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16
Q

macrolide resistance:
G+?
G-?

A

altered target site

inactivated by plasmid-associated esterase

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17
Q

ALL macrolides tx?

ALL are 1st line for?

A

pen-resistant S. pyogenes

diphtheria

18
Q

clarithromycin ? w/ food

A

increases absorption (erythro & azithro opposite)

19
Q

1st line for MAI, chlamydia pneum, diphtheria?

A

clarithro

20
Q

DOC - 1 dose for trachomatis

1st line diphtheria, legionnaires

A

azithro

21
Q

strept pneum resistant to ALL macrolides- Tx w/ ?

A

telithromycin (ketolide)

22
Q

telithro binds to ?

A

2 sites on 50s

23
Q

telithro:
only tx ? bc of liver damage
s/e?
CI?

A

CAP (resistant to macrolides)
jaundice, PROLONGED QT
<18

24
Q

a/g are bacterioCIDAL b/c they ?

A

inhibit protein synthesis IRREVERSIBLY

25
Q

a/g
SOA: all ? but NO ANAEROBES
limited G+ activity

A

gram neg bacilli

26
Q

a/g can tx ? when given w/ CWI!

A

meningitis (a/g don’t cross BBB)

27
Q

DOC for plague, tularemia

A

streptomycin

w/ yersinia aka black death/plague- +/-TCN

28
Q

a/g- gentamicin = exception bc?
>DOC for ? and ? from ? in combo w/
>infx assoc w/ ?
>also first line for MENINGITIS and bacteremia from ? or ? and can be employed with ? or ?

A
  • tx gram pos!
  • bacteremia, endocarditis; enterococcus; ampicillin, pen G, vancomycin
  • burns
  • strep agalactiae, listeria; penG, ampicillin
29
Q

tx brucella ?

A

genta & doxy

30
Q

1st line for bacteremia & pneum & UTIs due to pseudomonas?

A

tobramycin

31
Q

broadest spectrum a/g
resistant to inactivating enzymes
tx nosocomial infx i.e. enterobacter, serratia that are resistant to ? and ?

A

amikacin

genta, tobra

32
Q

? give orally for bowel sterilization & surgical prophy for hepatic coma
s/e?

A

neomycin

NM paralysis

33
Q

only for severe infix

back up for rickettsia and psitticosis

A

chloramphenicol

34
Q

prophy endo w/ pcn allergy

A

clindamycin

35
Q

fusobacterium givngivitis?

A

clindamycin

36
Q

clindamycin does NOT treat ?&raquo_space;narrow spectrum even though it treats ?
a/e?
concentrates in?

A

G- aerobes
G+ aerobes, G+ and - anaerobes
pseudo. colitis
bone! (like cefazolin)

37
Q

inhibits bacterial isoleucyl transfer-RNA synthase?
Bacteriocidal, Tx skin lesions and ? (G+cocci)
eradication of ? in health care workers

A

mupirocin
impetigo (topical)
MRSA (intranasally)

38
Q

related to a/g, bind to 30s, 3rd line treatment of gonorrhea

A

spectinomycin

39
Q

interacts w/ 23s rRNA and inh 50s?

SOA?

A

linezolid (zyvox)

G+ cocci, includes pneumonia & Ent. facials

40
Q

streptogramin-synercid
doesn’t treat?
only E. faecium
toxicity?

A

pneum

infusion phlebitis

Pharmacology (21 decks)

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