Pharmacology of Gastric Secretion Flashcards
what do mucus cells secrete
mucus
bicarbonate
what do parietal cells secrete
HCl
what do enterochromaffin-like cells secrete
histamine
what do G cells secrete
gastrin
what do D cells secrete
somatostatin
what do chief cells secrete
pepsinogen
how is HCl secreted from parietal cells
refer to PP
what triggers release of histamine
released in response to acetylcholine
what does histamine bind to
binds to H2 receptors with subsequent activation of adenylyl cyclase
what does ACh bind to
binds to muscarinic (M3) ACh receptors on parietal cells with subsequent activation of PLC
what does gastrin bind to
CCK2 receptors on parietal cells with subsequent activation of PLC
action of histamine
increase in cAMP increases the number of proton pumps - increasing gastric acid secretion from parietal cells
action of ACh
increase in intracellular Ca2+ evokes cell signalling pathways - increasing number of proton pumps, increasing gastric acid secretion from parietal cells
action of gastrin
The increase in intracellular Ca2+ increases the number of proton pumps, increasing gastric acid secretion from parietal cells
what does somatostatin bind to
SST2R receptorson enterochromaffin cells inhibiting adenylyl cyclase
