Pathology of Large Intestine Flashcards
describe diverticular disease of large bowel
common
related to low fibre diet and increased intra-lumenal pressure
symptoms of diverticular disease of large bowel
asymptomatic
symptoms only if complicated - requiring surgery
complications of diverticular disease of large bowel
inflammation rupture abscess fistula massive bleeding
describe ischaemia of large bowel
left sided disease
common in elderly
aetiology of ischaemia of large bowel
CVS disease AF embolus atherosclerosis of mesenteric vessels shock vasculitis
microscopic changes in ischaemic colitis
withering of crypts
pink smudgy lamina propria
fewer chronic inflammatory cells
complications of ischaemic colitis
massive bleeding
rupture
stricture
describe antibiotic-induced pseudomembranous colitis
patient on a broad spectrum of antibiotics - clostridium difficile selected out
toxin A and B attack endothelium and epithelium
symptoms of antibiotic-induced pseudomembranous colitis
diarrhoea
bleeding
treatment of antibiotic-induced pseudomembranous colitis
flagyl/vancomycin
colectomy
pathology of antibiotic-induced pseudomembranous colitis
patchy yellow membranous exudate on mucosal surface
microscopy of antibiotic-induced pseudomembranous colitis
explosive fibrinopurulent exudate on surface
describe collagenous colitis
patchy disease
thickened basement membrane associated with intraepithelial inflammatory cells
no chronic architectural changes (normal mucosa)
symptoms of collagenous colitis
watery diarrhoea!!
normal endoscopy
look at drug history
microscopy of collagenous colitis
increase in thickness of subepithelial collagen
