Pharmacology - Introduction to pharmacology : Molecular targets of drug action Flashcards
-pril
ace inhibitors
which bonds are most important in the binding of drugs to their molecular targets
a. covalent
b. ionic
c. hydrogen
b.ionic
which of these bonds are generally not involved in the binding of a drug to its target
a. ionic
b. hydrogen
c. covalent
c.covalent
lidocaine (local anaesthetic) is a blocker of the voltage gated sodium channel .what effect do blockers have on the ion channels
a. change their shape
b. increase their activity
c. decrease amount of time channel is open
d. block pore of the channel
d.block pore of the channel
how do allosteric modulators effect channel proteins
a. change their shape
b. increase their activity
c. decrease amount of time channel is open
d. block pore of the channel
e. change shape change on binding elsewhere
e.change shape change on binding elsewhere
what is the effect of a facilitator modulator on ion movement
a. more ions can enter
b. less ions can enter
a.more ions can enter
amlodipine is an example of a..
a. facilitator modulator
b. inhibitor modulator
b.inhibitor modulator
reduced time channel open reduces entry of calcium ions for smooth muscle contraction, so bloo vessel dilation and reduced blood pressure
diazepam works on the gaba gated cl- channel enhancing entry of cl- causing membrane hyperpolarisation and reduced anxiety it is an example of..
a. facilitator modulator
b. inhibitor modulator
b.inhibitor modulator
which of these drugs block the transport mechanism of membrane proteins
a. blockers
b. inhibitor modulators
c. facilitator modulator
d. inhibitor
e. false substrate
d. inhibitor
furosemide is an example of which type of drug?
a. blockers
b. inhibitor modulators
c. facilitator modulator
d. inhibitor
e. false substrate
d. inhibitor
targets na k cl transporter on surface of renal tubular cells to decrease salt and water resorption
which drug type compete with and prevent movement of a natural substrate (transported instead)
a. blockers
b. inhibitor modulators
c. facilitator modulator
d. inhibitor
e. false substrate
e.false substrate
amphetamine is an example of what type of drug
a. blockers
b. inhibitor modulators
c. facilitator modulator
d. inhibitor
e. false substrate
e.false substrate
lisinopril is an example of which type of drug
a. blockers
b. inhibitor modulators
c. facilitator modulator
d. enzyme inhibitor
e. false substrate
d. enzyme inhibitor
which type of drug first require conversion by an enyme from an inactive to an active form
a. pro drugs
b. inhibitor modulators
c. facilitator modulator
d. enzyme inhibitor
e. false substrate
a.pro drugs
eg perindopril and perindoprilat
infliximab binds to what
a. enzymes
b. transport proteins
c. ion channels
d. inflammatory protein mediators
d.inflammatory protein mediators
rheumatoid arthiritis treatment
