Genetics - DNA : Reading the code

Question 1

in pancreatic ductal adenocarcinoma pancreatic stellate cells are affected. this causes which of their receptors to that acts as a transcriptional regulator of PSCs to actiate the cells to reduce fibrosis and inflammation and enhance the efficacy of a coadministered chemotoxic agent

a. vit c
b. vit a
c. vit d

Answer 1

c. vit d

Question 2

DNA wrapped around histone proteins is known as..

a. Double helix
b. chromosomes
c. chromatin

Answer 2

c. chromatin

Question 3

how are histones modified to regukate access to dna

a,phosphorylation
b.acetylation

Answer 3

b.acetylation

Question 4

what affect does histone acetylation have on transcription

a. increase
b. decrease

Answer 4

a.increase

Question 5

in cancer therapy what is done to histones

a. acetylated
b. deacetylated

Answer 5

b.deacetylated

Question 6

what drug binds to a receptor that translocates to the nucleus and effects gene transcription

a. corticosteroids
b. glucocorticoids
c. mineralocorticoids

Answer 6

b.glucocorticoids

Question 7

which receptors act as transcription factors

a. mu
b. delta
c. pcsk9
d. oestrogen

Answer 7

d.oestrogen

Question 8

what enzyme tdo transcription factors interact with

a. dna polymerase
b. dna helicase
c. taq polymerase
d. dna ligase
c. rna polymerase

Answer 8

c. rna polymerase

Question 9

which is more common

a. transitions
b. transversions

Answer 9

a.transitions

Question 10

when a pyrimidine is swapped for another pyrimidine it is known as

a. transition
b. transversion

Answer 10

a. transition

Question 11

when a pyrimidine is swapped for a purine it is known as

a. transition
b. transversion

Answer 11

b. transversion

Question 12

a mutation in the promoter or non coding regions will have which effect

a. alter expression levels
b. change protein
c. stop translation

Answer 12

a. alter expression levels

Question 13

if the mutations causes the same amino acid to be coded for it is known as..

a. silent
b. nonsense
c. missense

Answer 13

a.silent

Question 14

if the mutations causes a different amino acid to be coded for it is known as..

a. silent
b. nonsense
c. missense

Answer 14

c. missense

Question 15

if the mutations causes a stop codon to be coded for it is known as..

a. silent
b. nonsense
c. missense

Answer 15

b. nonsense

Question 16

retinitis pigmentosa can be cause by 1 mutation type in one gene only

a. true
b. false

Answer 16

b.false

many mutation types in many genes

Question 17

which of these is not a component of PCR

a. target DNA
b. forward and reverse primers
c. deoxynucleotide triphosphates and buffer salts
d. DNA polymerase
e. RNA polymerase

Answer 17

e.RNA polymerase

Question 18

which of these can be detected using PCR

a. peptic ulcer
b. reflux disease
c. pregnancy
d. e coli
e. barrets oesophagus

Answer 18

a.peptic ulcer

Question 19

PCR, sequencing reaction, gel electrophoresis and reading off a single dna sequence describes which process

a. pcr
b. next generation genetic analysis
c. conventional dna sequencing

Answer 19

c. conventional dna sequencing

Question 20

which of these is not a use of next generation sequencing

a. mutation detection
b. pharmacogenomics
c. gene expression
d. microbiology
e. bioavailability

Answer 20

e. bioavailability

Question 21

personalised medicine is based on..

a. pcr
b. ngs

Answer 21

b.ngs