Immunology - Vaccine immunology Flashcards
MMR, polio,smallpox,rotavirus are examples of which type of vaccine
a. live
b. inactivated
c. subunit
a.live
hep a and rabies are examples of which type of vaccine
a. live
b. inactivated
c. subunit
b.inactivated
hep b, sars cov2, hpv are examples of which type of vaccine
a. live
b. inactivated
c. subunit
c.subunit
duration of protective immunity is generally ……………. in inactivated whole vaccines than live attenuated
a. lower
b. higher
a.lower
in which type of vaccine is a lyse culture used and the virus vaccine antigen is extracted and purified
a. live attenuated
b. inactivated whole
c. inactivated split
d. subunit
c.inactivated split
in what type of vaccine is made my cloning an antigen gene into an expression vector and purification then combination with adjuvants
a. live attenuated
b. inactivated whole
c. inactivated split
d. subunit
d.subunit
what is the role of adjuvants
a. enhance immune response to antigens
b. decrease immune response to antigens
a.enhance immune response to antigens
linear peptides and conformational peptides are examples of which type of epitope
a. b cell
b. t cell
a.b cell
antibodies recognise what level of structure in linear peptide b cell epitopes
a. primary
b. tertiary
a.primary
antibodies recognise what level of structure in conformational peptide b cell epitopes
a. primary
b. tertiary
b.tertiary
what epitope is found on cytotoxic t cells and is presented by MHC class I
a. cd4+
b. cd8+
b.cd8+
what epitope is found on helper t cells and is presented by MHC class II
a. cd4+
b. cd8+
a.cd4+
what phase of vaccine devlopment involves construction, formulation and animal models
a. 1
b. 2
c. 3
d. 4
e. pre clinical
d.pre clinical
what phase of vaccine devlopment involves small numbers of healthy volunteers (<100)
a. 1
b. 2
c. 3
d. 4
a.1
what phase of vaccine development involves large numbers of healthy volunteers and dose ranging eg 100-1000
a. 1
b. 2
c. 3
d. 4
b.2
