Cell biology - Extracellular matrix Flashcards
in most connective tissue what is ECM produced by
a. osteoblasts
b. fibroblasts
b.fibroblasts
what produce hydroxyapatite
a. fibroblasts
b. osteoblasts
b.osteoblasts
lysyl hydroxylase adds OH to lysines, prolyl hydroxylase adds OH to prolines
what do these processes require
a. H2o and vit c
b. iron and vit K
c. iron and vit C
c.iron and vit C
lysyl hydroxylase forms bonds between how many collagen molecules to form procollagen
a. 2
b. 4
c. 6
d. 3
d.3
which enzymes cleave propeptides to form tropocollagen
a. lysyl hydroxylase
b. collagen peptidases
c. lysyl oxidase
b.collagen peptidases
what does lysyl oxidase do?
a. bond forming between 3 collagen molecules
b. cleaving propeptides
c. slef assembly of tropocollagen to fibrils
c.slef assembly of tropocollagen to fibrils
ehlers danlos syndrome is caused by a mutation in the collagen / which enzyme
a. lysyl hydroxylase
b. collagen peptidases
c. lysyl oxidase
b.collagen peptidases
what is defected in epidermolysis bullosa
a. intercellular connections
b. skin to ECM
b. skin to ECM
mutations to laminin genes and in collagen 17A1 causes what
a. progeria
b. marfans
c. ehlers danlos
d. junctional epidermolysis bullosa
d.junctional epidermolysis bullosa
which of these has significant role in scar formation
a. osteoblasts
b. chondrocytes
c. fibroblasts
c. fibroblasts
what is caused by mutations in the gene for type IV collagen crucial for basement membranes in the kidney, ear and inner eye
a. progeria
b. marfans
c. ehlers danlos
d. junctional epidermolysis bullosa
e. alport syndrome
e.alport syndrome
what is the classic symptom of alport syndrome
a. peeling skin
b. cataracts
c. end stage renal disease
d. hearing loss
e. haematuria
e. haematuria
what do matric metalloproteinases do?
a. build ECM
b. degrade ECM
b.degrade ECM
critical for macrophage invasion during infection
what is applied as a treatment for diabetic ulcers
a. collagen
b. keratin
c. elastin
a.collagen
what do extracellular collagen - fibronectin bind to the actin cytoskeleton via
a. elastin
b. integrins
c. basal lamina
b.integrins
which of these substances is made up of proteins with covalently linked carbs
a. glycoproteins
b. proteoglycan
a.glycoproteins
which of these substances is made up of extra cellular proteins linked to complex -ve charged carbs (GAGs) , WITH SUGAR AS THE PREDOMINANT ELEMENT
a. glycoproteins
b. proteoglycan
b.proteoglycan
cell surface proteins eg blood group antigens are examples of..
a. glycoproteins
b. proteoglycan
a.glycoproteins
vit C defficiency causing a reduced collagen turnover leads to which condition
a. scurvy
b. metastaic breast cancer
c. marfans
d. ehlers danlos syndrome
e. marfans
a. scurvy
epithelial cells dettaching from the basal lamina , degrading the ECM and migrating to other tissues causes which condition
a. scurvy
b. metastaic breast cancer
c. marfans
d. ehlers danlos syndrome
e. marfans
b.metastaic breast cancer
a mutation in fibrillin leads to which condition
a. scurvy
b. metastaic breast cancer
c. marfans
d. ehlers danlos syndrome
e. marfans
c.marfans
the basal lamina is a specialised ECM of laminin and which type of collagen
a. I
b. II
c. III
d. IV
d.IV
laminin plays a similar role to what in CT
a. fibronectin
b. integrins
c. actin
a.fibronectin
defects in what structure can cause blistering diseases
a. desmosomes
b. tight junctions
c. gap junctions
d. hemidesmosomes
d.hemidesmosomes
