Pharmacology Flashcards
are endocrine glands ductless or have ducts?
ductless
what are 3 ways of specifying different signalling?
chemically distinct hormones, specific receptors and distribution of receptors across target cells
What are the two main endocrines in the body
pituitary and hypothalamus
what are some functions of the endocrine system?
regulate h2o and electrolyte balance, nutrient metabolism. Promote growth and development, control reproduction, regulate RBC production
how do endocrine glands travel?
In blood to site of cells
Oxytocin and insulin are what type of hormone?
glycoprotein and peptide
what is cortisol and testosterone hormone?
steroids
what type of hormone is adrenaline?
tyrosine
Are amines hydrophilic or hydrophobic?
hydrophilic
amines are transported freely?
yes
Ca exocytosis stimulates amine synthesis?
yes
peptides and proteins are not Ca driven and are transported bound
FLSE FALSE FLASE
Is steroids hydrophobic or hydrophilic?
hydrophobic
how are steroids transported /
bound 90% of the time
Are steroids stored?
NO
What is needed to transport steroids nd thyroxine?
carrier proteins
cortisol binding globulin binds what?
cortisol
What is thyroxine bound by
thyroxine binding globulin
what does sex steroids binding globulin bind?
testosterone and estradiol
do proteins and peptides require transportation?
noooooo
can free or bound hormones transport across capillary wall?
free
How does hormone get eliminated form the body?
metabolism by the liver and excretion by the kidneys
what are receptor kinases activated by?
proteins and peptides
What are g protein coupled receptors activated by?
amines
what isdoesclass 1 nuclear receptors activated by?
steroids
what is the hybrid class activated by?
thyroid hormone
what is class 2 nuclear receptors activated by
lipids
