Hyper/hypothyroidism Flashcards
what is the most commonest form of thyroid disease
autoimmune
what 3 things do you use to measure thyroid hormone?
TSH, T3/4
in primary hyperthyroidism, is TSH high or low
low TSH, high T3/4
in primary hypothyroidism is TSH high or low, T3/4 high or low
TSH high, T3/4 low
In secondary hyperthyroidism, what are the TSH and T3/4 levels
High for both
In secondary hypothyroidism is TSH and T3/4 high or low
low
what does myxoedema coma refer to?
severe hypothyroidism
what are 2 common cause of primary hypothyroidism
hashimotos thyroiditis and iodine deficiency
what are non goitrous causes of hypothyroidism?
radioiodine, atrophic thyroiditis
what biochemistry markers are noted in hashimotos thyroidits
thyroid peroxidase antibodies in blood, T cell infiltrate and inflammation
what are some signs and symptoms of hypothyroidism
dull expression, pale skin, vitiligo, cold intolerance and pitting oedema, decreased appetite and weight gain
what would lab results show for hypothyroidism
High TSh, Low T3/4, increased CK, increased LDL,
how do you manage hypothyroidism
young: thyroxine 50-100micrograms, elderly: 25-50 micrograms. Check TSH 2 months after dose change
Should you increase thyroxine dose during pregnancy?
of course
what would you find in patients with myxoedema coma
bradycardia, Type 2 resp failure, adrenal failure
