Pharmacology

Question 1

ACE inhibitor contraindications

Answer 1

pregnancy (unless essential)
history of angioedema
caution with hyperkalemia

Question 2

ACE inhibitor side effects

Answer 2

dry cough
angioedema
constipation/diarrhoea

Question 3

ARBs

Question 4

beta blockers contraindications

Answer 4

asthmatic

Question 5

CCB side effects

Answer 5

constipation
gingival overgrowth
peripheral edema

Question 6

two classes of CCB

Answer 6

di-hydropyridine (non rate limiting) and non di-hydropyridine (rate limiting)

Question 7

MOA of dihydropyridine CCBs

Answer 7

vasodilation
reduces systemic vascular resistance

Question 8

moa of aspirin

Answer 8

inhibits COX and prevents production of thromboxane A2

Question 9

examples of P2Y-12 inhibitors

Answer 9

clopidogrel
ticagrelor
prasrugrel

Question 10

MOA of P2y-12 inhibitors

Answer 10

inhibits adenosine diphosphate receptor
prevents platelet aggregation

Question 11

MOA of warfarin

Answer 11

inhibits synthesis of vitamin K dependant clotting factors
2, 6, 9, 10

Question 12

MOA of DOAC

Answer 12

inhibits factor 10A

Question 13

MOA of nitrates

Answer 13

produce nitric oxide which causes vasodilation

Question 14

side effects of nitrates

Answer 14

headaches
flushing

Question 15

loop diuretic side effects

Answer 15

hyperuricemia
hypokalaemia
gout
ototoxicity

Question 16

thiazide diuretic side effects

Answer 16

hypokalaemia, hyperuricemia

Question 17

statin MOA

Answer 17

inhibits HMG Co-reductase
prevent lipid synthesis in the liver

Question 18

side effects of statins

Answer 18

myositis
abnormal LFTs
rhabdo

Question 19

MOA of digoxin
effect on chonotropy and inotropy?

Answer 19

inhibits the sodium potassium pump
-ve chonotrope
+ve inotrope