Pharm COPY Flashcards
Name some drugs that should be avoided in the elderly
Antihistamines (benydryl) TCA's Benzo Sulfonylureas Indimethicin
Drug of choice for the treatment of paroxysmal supra ventricular tachycardia
Adenosine
Action of adenosine
Slows conduction through the AV node by hyper polarizing the nodal pacemaker and conducting cells
Side effects of adenosine
Flushing, chest burning (bronchi spams ) and hypotension
Drug used for chemical cardiac stress test
Adenosine
Name two drugs that are metabolized by methylation
6-MC
Azathioprine
Name a syndrome associated with a dysfunction of glucuronyl transferase system that can lead to the toxic accumulation of some drugs because of the lack of glucuronidation
Gilbert syndrome
Bilirubin is metabolized by what method
Glucuronidation
Chest pain that occurs with activity only
Stable angina
Why avoid nitrates in HOCM
Because they decrease left ventricular volume which worsens left ventricular tract obstruction which worsens the situation
Raynuad is associated with what drugs
Amphetamines
Ergotamine
Chemo drugs
The ability for a drug to illicit and effect?
Efficacy
The dose of a drug that is needed to produce a given effect
Potency
Lower ED 50 means what?
A greater amount of potency
What does the stimulation of D1 do
Raises cAMP and causes vasodilation in most arterial beds and decreases BP
What is a D1 receptor short acting agonist used in severe HtN
Fenoldopam
A drug that causes renal vasodilation and increases naturesis. Mainly used for HTN emergency
Fenoldopam
Name a drug that is responsible for inhibiting GP 2b/3a from binding to fibrinogen stabilizing a platlet plug
Abciximab
What does Argatroban treat
Heparin induced thrombocytopenia
How does clopidgrel block platlet Adp receptors
By blocking P2Y12
Three drugs that can cause aplastic anemia
Carbamazepine
Chloramphenicol
Sulfonamides
Side effects of gentamicin
Vestibular and cochlear ototoxicity and nephrotoxicity
What happens when metronidazole is taken with alcohol
Disulfiram like reaction
What is used for heparin reversal
Protamine
At high doses what does desmopressin do
Increases factor eight activity in hemophilia a and Von willebrand disease patients
Drug thy treats hyperemesis gravidarum
Promethazine (antihistamine drug)
Antihistamine drugs that treat vomiting
Diphenhydramine
Meclizine
Promethazine
Dopamine receptor antagonist drugs that treat vomit
Prochlorperazine
Metoclorpramide
Neurokin 1 receptor antagonist that treat chemo associated vomiting
Aprepitant
Fosaprepitant
Five receptors associate with the area prostrema (vomiting)
M1 D2 H1 Serotonin Neurokinin 1
A drug that is a motilin that is used for gastroparesis
Erythromycin
What is the neurotransmitter that plays a role in pain and appetite and is found in the ANS
Neuropeptide Y
Ganciclovir treats CMV and had a UDE of what
Neutropenia
Adding TMP-SMX to ganciclovir causes what
Bone marrow suppression
Didansoine is an antiretroviral drug that can cause what adverse reaction
Pancreatitis
What are plasma cells susceptible to
Proteosome inhibitors called
Bortezomib
Boronic acid containing dipeptide
(Induce apoptosis in malignant plasma cells)
Heparin induced thrombocytopenia leads to thrombosis not bleeding and is associated with antibodies to what
Factor 4 and heparin
Decreased factor 8 is associated with hemophilia?
A
Decreased factor nine is associated with hemophilia?
B
People with hemophilia a can control bleeding with what
DDAVP (desmopressin)
Drug of choice for beta blocker overdose
Glucagon
Action of glucagon on the heart
It increases cAMP and increases heart rate and contractility
Burning in urination and urgency is a side effect associated with what anti cancer drug
Cyclophosphamide
Ant cancer drug that causes progressive pulmonary fibrosis that can cause death in some patients
Bleomycin
Mercaptoourine is associated with what side effect
Jaundice and abdominal pain
Monoclonal antibody used for RA and Ankylosing Spondylitis (antibody against TNF alpha)
Infliximab
IL 2 treats what two things
Renal cell carcinoma and melanoma
Drug that inhibits BCR/ABL AND treats CmL
Imatinib
What turns Uric acid into allantoin which is more soluble then Uric acid. Used in tumor lysis syndrome
Rasburicase
Drug used to counter methotrexate induced block of folic acid metabolism
Folinic acid (leucovorin)
What activates 6MCP
hGPRT
What inactivated 6MCP
Xanthine oxidase
What is the use for Cladribine
Hair cell leukemia (resistant to the degradation of ADA)
What is a drug that can cause prolonged QT but not likely to cause torsades de pointes
Amiodarone
What to give to partners with aspirin allergy who need a cardio protective drug
Clopidgrel
What drug causes an increases in LDl cholesterol and triglycerides because it increases insulin resistance in peripheral tissue
Thiazides
hormones that use cAMP
- TSH
- ACTH
- HCG
what is P-glycoprotein
it is a human multi drug resistance transmembrane ATP-dependent efflux pump protein that reduces the influx of drugs into the CNS, blocking the action of chemotherapeutic agents
