Pharm basics Flashcards
what order of elimination is this?
What drugs are limited this way?
Zero order elimination
Phenytoin, Ethanol, and Aspirin
What drugs are eliminated this way?
What order is this?
many drugs
First order
When discussing drug interactions:
Effect of substance A and B together is equal to the sum of their individual effects
Additive
When discussing drug interactions:
What is presence of substance A is required for the full effects of substance B?
Permissive
When discussing drug interactions:
What is the effect of substance A and B is greater together than the sum of their individual effects
synergistic
What is the acute decrease in response to a drug after initial/repeated administration?
Tachyphylatic
Volume of distribution is low
What comparment is my drug usually located in?
What is the drug type?
Intravascular
Large/charged molecules; plasma protein bound
When the volume of distribution is medium
What compartment is it in?
What is the drug type?
ECF
Small hydrophilic molecules
What is the large volume of distribution
What compartment is it usually?
What is the drug type?
All tissues regarding fat
Small lipophilic molecules
When there is renal or liver disease what happens to the mainteance dose and the loading dose?
Maintenance dose is lower
Loading dose is unchanged
Time to steady state depends primarily on what?
half life
Independent of dose and
dosing frequency
Reduction
Oxidation
Hydrolysis
These three things occur with cytochrome P-450
What phase is this?
Phase 1
What phase are we in now?
Conjugation which is
Methylation
Glucuronidation
Acetylation
Sulfation
Phase II of drug metabolism
What is an indirect agonist: anticholinesterase that doesnt cross the BBB?
Is this a polar or nonpolar drug?
Neostigmine
Polar
What is the indirect agonist that crosses the blood brain barrier freely?
Is this a polar or non polar drug?
Physostigmine
Non-polar
What drug is an indirect agonist, anticholinesterase, that is used for myasthenia gravis?
Does it penetrate the CNS?
Pyridostigmine
No
When D1 is stimulated, what is the MOA, via the G(s) pathway?
Relaxes renal vascular smooth muscle
When there is D2 agonist, G(i), what is the MOA, non psych stuff?
Modulates transmitter release, especially in brain
What is the ending for -ximab mean?
Chimeric human-mouse monoclonal Ab
What does the ending of -zumab, stand for?
Humanized mouse monoclonal antibody
What does the suffix -umab stand for?
Human monoclonal Antibody
What does the ending -tinib inhibit?
tyrosine kinase inhibitor
What does -zomib inhibit?
Proteasome inhibitor
What does the -ciclib inhibit?
cyclin-dependent kinase inhibitor
What does the ending of -cept stand for?
TNF-alpha antagonist
What does the ending -leukin stand for or go after?
IL-2 agonist/analog
What does the ending of -kinra stand for work on?
Interluekin receptor antagonist
In the world of Hep C drugs:
What inhibits NS5A, a viral phosphoprotein that plays a key role in RNA replication?
Ledipasvir and Ombitasvir “North Sea in Sketchy”
In the world of Hep C:
What inhibits NS5B, and RNA dependent RNA polymerase acting as a chain terminator?
Sofosbuvir and Dasabuvir
THis is the sofa couch in sketchy
What inhibits NS3/4A a viral protease preventing viral replication?
Grazoprevir and Simeprevir
This is the “stuck machette” in sketchy
What is/are the side effects of
Grazoprevir
Simeprevir
?
Grazoprevir: Photosensitivity reactions (camera)
Simeprevir: Headache and Fatigue
