Odd stuff 3 Flashcards
What is Bortezomib and carfilzomib used for?
proteasome inhibitors, induce arrest at G2-M, apoptosis, not in sketchy
What is Trastuzumab used for?
Monoclonal antibody against HER 2, a tyrosine kinase receptor, tapestry weaver
What is the Vemurafenib used for?
Small molecule inhibitor of BRAF oncogene melanoma, “venom” on the “Dont tread on me” flag, Multiple Myeloma
What is Rasburicase used for?
synthetic move from uric acid to allantoin, not in sketchy
Sunitinib and Soratinib inhibit what? They are not in First Aid, sketchy only
VEGF, flowers in the sketchy video, can be used in RCC
What does BAX and BAK are what? What does Bcl-2 and BCL-x are what?
proapoptotic antiapoptotic
What immunosuppresant drug blocks cyclophilin, prevents IL-2? What is a problem with it
gingival hyperplasia, nephrotoxic cyclosporine
What immunosuppresant drug blocks FK506, preventing IL-2? What is good about it?
No nephrotoxicity, no gingival hyperplasia, and no neurotoxicity Tacrolimus
What immunosupressant hits mTOR, blocks mTOR and is not nephrotoxic?
Sirolimus (Rapamycin), not nephrotoxic
What -mab blocks IL-2R?
Basiliximab
When a graft is from yourself, what is it?
autograft
When a graft is from an identical twin or clone?
Isograft
When a graft is from a non-identical individual of same species?
Allograft
What a graft is from a different species, what is it?
Xenograft
What toxin is from a pufferfish? What is the MOA?
Tetrodotoxin, binds fast voltage-gated Na+, prevents depolarization
What toxin is from a reef fish such as a barracuda, snapper, and moray eel?
Opens Na channels, depolarization Ciguatoxin
What toxin is from a dark meat fish, such as tuna, mahi mahi? What is the MOA?
Histamine bacterial histidine decarboxylase prevents histidine to histamine, usually misdiagonsed as a fish allergy
What -mab rapidly reverses Dagtroban?
Idarucizumab
When we have anemia, and we want to stimulate/have an increase in erythroppietin, what drug do we give?
Epoetin alfa
What drug increases granulocytes?
What drug increases monotcyte counts too?
Filgrastim
Sargramostim
What is a Romiplostim?
What is an eltrombopag?
TPO analog
TPO receptor agonist
When D1 is stimulated, what is the MOA, via the G(s) pathway?
Relaxes renal vascular smooth muscle
When there is D2 agonist, G(i), what is the MOA, non psych stuff?
Modulates transmitter release, especially in brain
What is the ending for -ximab mean?
Chimeric human-mouse monoclonal Ab
What does the ending of -zumab, stand for?
Humanized mouse monoclonal antibody
What does human monoclonal antibody -umab?
Human monoclonal Antibody
What does the ending -tinib inhibit?
tyrosine kinase inhibitor
What does -zomib inhibit?
Proteasome inhibitor
What does the -ciclib inhibit?
cyclin-dependent kinase inhibitor
What does the ending of -cept stand for?
TNF-alpha antagonist
What does the ending -leukin stand for or go after?
IL-2 agonist/analog
What does the ending of -kinra stand for work on?
Interluekin receptor antagonist
In the world of Hep C drugs:
What inhibits NS5A, a viral phosphoprotein that plays a key role in RNA replication?
Ledipasvir and Ombitasvir “North Sea in Sketchy”
In the world of Hep C:
What inhibits NS5B, and RNA dependent RNA polymerase acting as a chain terminator?
Sofosbuvir and Dasabuvir
THis is the sofa couch in sketchy
What inhibits NS3/4A a viral protease preventing viral replication?
Grazoprevir and Simeprevir
This is the “stuck machette” in sketchy
What is/are the side effects of
Grazoprevir
Simeprevir
?
Grazoprevir: Photosensitivity reactions (camera)
Simeprevir: Headache and Fatigue
What disease is CA 15-3/CA 27-29?
Breast Cancer
What disease is CA 19-9?
Pancreatic adenocarcinoma
What disease is CA 125?
Ovarian Cancer
What does Good Syndrome have?
Hypogammaglobulinemia, there is a B cell and T cell immunodeficiency
What does migratory superficial thrombophelbitis show up in?
Trousseau Syndrome
What nonbacterial thrombotic endocarditis have that can lead to adenocarcinomas, especially pancreatic?
Nonbacterial Thrombotic Endocarditis
Deposition of sterile platelet thrombi on heart valves
What is anti-NMDA receptor encephalitis show up in?
Ovarian teratoma, not in sketchy
What does neuroblastoma and small cell lung cancer diseases cause?
Opsoclonus-myoclonus ataxia syndrome
What disease has anti-Hu antibodies? name 2
Small Cell Lung Cancer and paraneoplastic encephalomyelitis
What disease has anti-Yo antibodies?
OBGYN and Breast Cancer
What disease has anti-Tr antibodies?
Hodgkin Lymphoma
What stains positive for cytokeratin?
SCC Epithelial cells
Error of morphogenesis: Absent organ due to absent primordial tissue
Agenesis
Error of morphogenesis: Absent organ despite presence of primordial tissue
Aplasia
Error of morphogenesis: Incomplete organ development; primordial tissue present
Hypoplasia
