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Odd stuff 3 Flashcards

1
Q

What is Bortezomib and carfilzomib used for?

A

proteasome inhibitors, induce arrest at G2-M, apoptosis, not in sketchy

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2
Q

What is Trastuzumab used for?

A

Monoclonal antibody against HER 2, a tyrosine kinase receptor, tapestry weaver

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3
Q

What is the Vemurafenib used for?

A

Small molecule inhibitor of BRAF oncogene melanoma, “venom” on the “Dont tread on me” flag, Multiple Myeloma

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4
Q

What is Rasburicase used for?

A

synthetic move from uric acid to allantoin, not in sketchy

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5
Q

Sunitinib and Soratinib inhibit what? They are not in First Aid, sketchy only

A

VEGF, flowers in the sketchy video, can be used in RCC

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6
Q

What does BAX and BAK are what? What does Bcl-2 and BCL-x are what?

A

proapoptotic antiapoptotic

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7
Q

What immunosuppresant drug blocks cyclophilin, prevents IL-2? What is a problem with it

A

gingival hyperplasia, nephrotoxic cyclosporine

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8
Q

What immunosuppresant drug blocks FK506, preventing IL-2? What is good about it?

A

No nephrotoxicity, no gingival hyperplasia, and no neurotoxicity Tacrolimus

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9
Q

What immunosupressant hits mTOR, blocks mTOR and is not nephrotoxic?

A

Sirolimus (Rapamycin), not nephrotoxic

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10
Q

What -mab blocks IL-2R?

A

Basiliximab

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11
Q

When a graft is from yourself, what is it?

A

autograft

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12
Q

When a graft is from an identical twin or clone?

A

Isograft

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13
Q

When a graft is from a non-identical individual of same species?

A

Allograft

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14
Q

What a graft is from a different species, what is it?

A

Xenograft

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15
Q

What toxin is from a pufferfish? What is the MOA?

A

Tetrodotoxin, binds fast voltage-gated Na+, prevents depolarization

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16
Q

What toxin is from a reef fish such as a barracuda, snapper, and moray eel?

A

Opens Na channels, depolarization Ciguatoxin

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17
Q

What toxin is from a dark meat fish, such as tuna, mahi mahi? What is the MOA?

A

Histamine bacterial histidine decarboxylase prevents histidine to histamine, usually misdiagonsed as a fish allergy

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18
Q

What -mab rapidly reverses Dagtroban?

A

Idarucizumab

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19
Q

When we have anemia, and we want to stimulate/have an increase in erythroppietin, what drug do we give?

A

Epoetin alfa

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20
Q

What drug increases granulocytes?

What drug increases monotcyte counts too?

A

Filgrastim

Sargramostim

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21
Q

What is a Romiplostim?

What is an eltrombopag?

A

TPO analog

TPO receptor agonist

22
Q

When D1 is stimulated, what is the MOA, via the G(s) pathway?

A

Relaxes renal vascular smooth muscle

23
Q

When there is D2 agonist, G(i), what is the MOA, non psych stuff?

A

Modulates transmitter release, especially in brain

24
Q

What is the ending for -ximab mean?

A

Chimeric human-mouse monoclonal Ab

25
Q

What does the ending of -zumab, stand for?

A

Humanized mouse monoclonal antibody

26
Q

What does human monoclonal antibody -umab?

A

Human monoclonal Antibody

27
Q

What does the ending -tinib inhibit?

A

tyrosine kinase inhibitor

28
Q

What does -zomib inhibit?

A

Proteasome inhibitor

29
Q

What does the -ciclib inhibit?

A

cyclin-dependent kinase inhibitor

30
Q

What does the ending of -cept stand for?

A

TNF-alpha antagonist

31
Q

What does the ending -leukin stand for or go after?

A

IL-2 agonist/analog

32
Q

What does the ending of -kinra stand for work on?

A

Interluekin receptor antagonist

33
Q

In the world of Hep C drugs:

What inhibits NS5A, a viral phosphoprotein that plays a key role in RNA replication?

A

Ledipasvir and Ombitasvir “North Sea in Sketchy”

34
Q

In the world of Hep C:

What inhibits NS5B, and RNA dependent RNA polymerase acting as a chain terminator?

A

Sofosbuvir and Dasabuvir

THis is the sofa couch in sketchy

35
Q

What inhibits NS3/4A a viral protease preventing viral replication?

A

Grazoprevir and Simeprevir

This is the “stuck machette” in sketchy

36
Q

What is/are the side effects of

Grazoprevir

Simeprevir

?

A

Grazoprevir: Photosensitivity reactions (camera)

Simeprevir: Headache and Fatigue

37
Q

What disease is CA 15-3/CA 27-29?

A

Breast Cancer

38
Q

What disease is CA 19-9?

A

Pancreatic adenocarcinoma

39
Q

What disease is CA 125?

A

Ovarian Cancer

40
Q

What does Good Syndrome have?

A

Hypogammaglobulinemia, there is a B cell and T cell immunodeficiency

41
Q

What does migratory superficial thrombophelbitis show up in?

A

Trousseau Syndrome

42
Q

What nonbacterial thrombotic endocarditis have that can lead to adenocarcinomas, especially pancreatic?

A

Nonbacterial Thrombotic Endocarditis

Deposition of sterile platelet thrombi on heart valves

43
Q

What is anti-NMDA receptor encephalitis show up in?

A

Ovarian teratoma, not in sketchy

44
Q

What does neuroblastoma and small cell lung cancer diseases cause?

A

Opsoclonus-myoclonus ataxia syndrome

45
Q

What disease has anti-Hu antibodies? name 2

A

Small Cell Lung Cancer and paraneoplastic encephalomyelitis

46
Q

What disease has anti-Yo antibodies?

A

OBGYN and Breast Cancer

47
Q

What disease has anti-Tr antibodies?

A

Hodgkin Lymphoma

48
Q

What stains positive for cytokeratin?

A

SCC Epithelial cells

49
Q

Error of morphogenesis: Absent organ due to absent primordial tissue

A

Agenesis

50
Q

Error of morphogenesis: Absent organ despite presence of primordial tissue

A

Aplasia

51
Q

Error of morphogenesis: Incomplete organ development; primordial tissue present

A

Hypoplasia

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