Odd Stuff 2 Flashcards
Error of morphogenesis: Secondary breakdown of previously normal tissue or structure (amniotic band syndrome)
Disruption
Error of morphogenesis: Extrinsic disruption, multiple gestation, crowding, foot deformities, occurs after embryonic period
Deformation
Error of morphogenesis Intrinsic disruption; occurs during embryonic period (weeks 3-8)
Malformation
Error of morphogenesis: Abnormalities result from a single primary embryologic event, i.e. Potter
Sequence
What do integrins bind too?
bind to fibronectin and laminin
In the world of antibiotics: What inhibits binding of the 50S subunit, prevents formation of the initiation complex? Am I bacteriostatic or bactericidal?
Linezolid Variable (first aid)
In the world of antibiotics: What causes the irreversible inhibition of initiation complex through binding of the 30S subunit, causes misreading of mRNA, blocks translocation? Am I bacteriostatic or bactericidal?
Aminoglycoside Bacteriocidal No anaerobic coverage here
In the world of antibiotics: What binds to 30S and prevents attachment of aminoacyl-tRNA; limited CNS penetration? Am I bacteriostatic or bactericidal?
Tetracyclines, causes misreading of the mRNA Bacteriostatic
In the world of antibiotics: What binds to the 30S, inhibits protein synthesis? Am I bacteriostatic or bactericidal?
Glycylcyclines Bacteriostatic
In the world of antibiotics: What blocks peptidyltransferase at 50S ribosomal subunit? Am I bacteriostatic or bactericidal?
Chloramphenicol Bacteriostatic Look out for Gray baby
In the world of antibiotics: What blocks peptide transfer (translocation) at 50S ribosomal subunit? Am I bacteriostatic of bactericidal?
Clindamycin Bacteriostatic Anaerobic coverage
In the world of antibiotics: What inhibits protein synthesis by blocking translocation; binds to the 23S rRNA of the 50S ribosomal subunit? Am I bacteriostatic of bactericidal?
Macrolides Bacteriostatic
Vasculitus: when we are a small vessel vasculitis, and come back positive for HLA-51, what two diseases could they be?
HSV or Parvovirus Behcet Syndrome
What vasculitus shows up with heavy smokers?
Buerger Disease (Thromboangiitis)
CYP-1A2 breaks down what?
Acetaminophen
What does the CYP 2E1 break down?
Ethanol
What does CYP 2C9 break down?
Warfarin/Coumadin
What does the CYP 2D6 break down?
Cardio Drugs
What does the CYP 3A4 break down?
Most Common
Rheumatoid Nodules + Pneumoconiosis is what?
Caplan Syndrome
Rheumatoid Nodules
Neutropenia
Splenomegaly
What is this?
Felty Syndrome
Epithelial Cells cause what kind of cancer?
What does it stain for?
Squamous Cell Carcinoma
Cytokeratin
What does mesenchymal tissue stain for?
What kind of cancer does it stain positive for?
Vimentin (fibroblasts, endothelial cells, macrophages)
Sarcoma, mostly
Sarcoma stains positive mostly for sarcomas, what are the other three things it stains positive for?
RCC
Meningoma
Endometrial Carcinoma
What does Bloom Syndrome have that is defective?
DNA helicase
What CYP enzyme breaks down omperazole, diazepam, citaolpram, clopidogrel?
CYP-2C19
What disease is HLA A3?
Hemochromatosis
What disease B8 only?
Myasthenia Gravis
What HLA is for Psoriatic arthritis, Ankylosing Spondylitis, IBD-associated arthritis, Reactive Arthritis?
HLA-B27
What HLA is Psoriasis?
HLA-C
What disease is HLA DQ2/ DQ8?
Celiac Disease
What HLA is for Multiple Sclerosis, Hay Fever, Goodpasture Syndrome?
DR2
What HLA is Rheumatoid Arthritis?
DR4
What disease is HLA B8 and HLA DR3?
Graves Disease
What disease is HLA DR2 and DR3?
SLE
What disease is HLA B8, DR3, DR4?
Addison Disease
What disease is DR3 and DR5?
Hashimoto Thyroiditis
What HLA is DM type 1?
DR3 and DR4
