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BOARDs > Pharm: Anti-psychotics/Anxiolytics/sedatives/ > Flashcards

Pharm: Anti-psychotics/Anxiolytics/sedatives/ Flashcards

1
Q

Antipsychotics

A

Calm the brain down

Tx Schizophrenia

1st Gen: D2 Blocker (Dopamine)
* Haloperidol
* Phenothiazines

2nd Gen: D & 5-HT Blocker (Dopamine & Serotonin)
* Clozapine

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2
Q

Antidepressants

A

Stimulate the CNS

For depression

SSRI:

SNRI/TCA:

MAOI:

Lithium

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3
Q

SSRI

A

Selective serotonin reuptake inhibitors
* Increase serotonin in synapse
* Antidepressant

Drugs:
* Fluoxetine
* Citalopram
* Trazodone

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4
Q

SNRI/TCA

A

Serotonin and NE reuptake inhibitor
* Antidepressant

Drugs:
* Amitriptyline
* Imipramine

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5
Q

MAOI

A

Monoamine Oxidase Inhibitors
* Dont use levonordephrine! Increase BP to much
* Antidepressant

Drugs:
* Phenelzine
* Tranylcypromine

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6
Q

Lithium

A

Tx Manic depression (bipolar)

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7
Q

Anxiolytics

A

Aka Sedatives

For anxiety or sedation

Benzodiazepines

Barbiturates

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8
Q

Benzodiazepines

A

Anxiolytic/Sedative

Increase GABA binding and Cl- ion influx to slow down the CNS
* ideal drug for oral sedation dentistry
* Propylene gycol induces thrombophelbitis in large veins

Drugs:
* Diazepam: 2-10 mg 1 hr b4 appt
* Triazolam
* Chlordiazepoxide

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9
Q

Benzodiazepines vs Barbiturates

A

Benzos:
* Increase therapeutic window
* Decrease Respiratory depresssion
* Decrease Addiction potential
* Safer

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10
Q

Barbituates

A

Anxiolytic/Sedative

Increase GABA binding & Cl ion influx to slow down CNS
* Same MOA as Benzos
* NOT ANALGESIC

Contraindications:
* Intermittent porphyria
* OD causes respiratory depressoin=Death

Drugs:
* ** Thiopental**: quick onset, short duration

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11
Q

General Anesthetics

A

The more soluble the agent in blood, the more you need to reach critical tension in the brain

Drugs:
* Halothane: caution w/hepatotoxcity

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12
Q

General Aneshetics: Stages

A

Stage 1: Analgesia
Stage 2: Delirium
Stage 3: Surgical Anesthesia
Stage 4: Medullary Paralysis

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13
Q

What causes Parkinson’s Disease?

A

Dopamine deficiency in the brain
* substantia nigra to striatum=main pathway

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14
Q

Benzodiazepines vs Barbituates

A

Benzos advantages vs barbiturates:
* less adiction potential
* Less profound CNS depression
* Larger therapeutic index
* less respiratory depression

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15
Q

Levodopa

A

Sympathomimetic:
* produces sympathetic stimulation in periphery
* Precursor to DOpamine
* Can cross BBB

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16
Q

Carbidopa

A

Blocks dopa Decarboxylase in periphery

17
Q

Parkinson’s Tx:

A

L-Dopa + Carbidopa

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