Pharm: Adrenergics Flashcards
Adrenergic Receptors
SNS-fight or flight response
Binds E/NE
* metabotropic: G- protein coupled receptor
Synethesis of E & NE
Catecholamines
Dopamine
NE
E
Monoamines
Dopamine
NE
E
Serotonin (5-HT)
Histamine
a1 vs a2 vs b1 vs b2
a1: Smooth muscle of vessels
* vasoconstriction
* Urination retention
* Pupil dilation (Mydriasis)
a2: Smooth muscle of vessels
* vasoconstriction
B1: Heart (SA & AV Nodes)
* Tachycardia= Increased HR, electrical condution, sterghtn of contraction (Inotropy)
* Juxtaglomerular cells of kidney–>Release renin->Angiotensinogen to Angiotensin 1
B2: Smooth muscle
* Bronchodilation
* Vasodilation
* Stop peristalsis
Adrenergic Agonists
Adrenergic Antagonists
Sympathomimetics
Dont bind to a or b receptors
* mimic sympathetic agonists
Sympatholytics
Dont bind to a or b receptors
*. mimic sympathetic antagonists