Phagocytosis

Question 1

Process of Phagocytosis

Answer 1

Initiation 
Chemotaxis
Recognition
Ingestion
Digestion
Excretion

Question 2

Oxidative Burst/Respiratory burst through engulfment of cell by wbcs

Answer 2

Phagocytosis

Question 3

Process which cells adhere to the vascular system as a result of damage and trauma which increases surface receptors

Answer 3

Initiation

Question 4

Cell receptors involved in the Initiation stage

Answer 4

CR3
Laminin receptor
Leucyl-formyl-methionyl phenylalanine receptors

Question 5

Dominant phagocytic complement receptor in humans

Answer 5

CR3

Question 6

Most potent PMN chemotactic factor;

Answer 6

Leucyl-formyl-methionyl phenylalanine receptors

Question 7

Process which cells move to the site of injury under influence of chemotaxins

Answer 7

Chemotaxis

Question 8

Potent chemo-attractants

Answer 8

C5a

C3a

Question 9

Impaired chemotaxis

Answer 9

Job Syndrome

Question 10

Lab Tests in Chemotaxis

Answer 10

Boyden Chamber Assay

Migration through Agarose gel

Question 11

Process which cells discriminate self and non-self component

Answer 11

Recognition

Question 12

2 mechanisms of Recognition

Answer 12

Direct Recognition

Indirect Recognition

Question 13

Direct Recognition

Via:
Recognizes:

Answer 13

Direct Recognition

Via: Primitive Pattern Recognition Receptors
Recognizes: Pathogen Associated Molecular Patterns (PAMPS) on microorganisms

Question 14

Indirect Recognition

Via:
Recognizes:

Answer 14

Indirect Recognition

Via: Opsonization
Recognizes: Opsonins coating the microorganisms

Question 15

Most common Opsonins

Answer 15

C3b, iC3, C4b, IgG

Question 16

______ coats/marks the microorganisms to facilitate increase phagocytosis by easily identifying antigens

Answer 16

Opsonins

Question 17

Opsonins attach to the ______ of the antigens

Answer 17

Epitope

Question 18

Antigenic determinant

Answer 18

Epitope

Question 19

Process of cell eating which forms projections/cytoplasm extends out in the microorganisms

Answer 19

Ingestion

Question 20

Steps in Ingestion

Answer 20

Pseudopod formation
Phagosome formation
Phagolysosome formation

Question 21

_________ is a phagosome fused with cytoplasmic granules

Answer 21

Phagolysosome

Question 22

Ingestion is enhanced by:

Answer 22

Opsonins

Surfuctants

Question 23

Ingestion is inhibited by capsulated bacteria: ____________, ____________, ____________.

Answer 23

H. influenzae
S. pneumoniae
N. miningitidis

Question 24

Microorganism inside the cell or a vacoule

Answer 24

Phagosome

Question 25

Refers to the killing of microorganism

Answer 25

Digestion/Destruction

Question 26

Destructon

Answer 26

Once fused granules degranulates, digestive enzymes promotes killing or oxidative burst of the microorganism

Question 27

Effective Killing of the Microorganisms

Answer 27

Peroxidases: H2O2, Superoxide anion, NADPH oxidases

Question 28

Lysosomal contents

Answer 28

Lysozymes, Lactoferrins, Defensins

Question 29

Defect in Lysosomal Enzyme Activity

Answer 29

Chediack Higashi Syndrome

Question 30

Defect in NADPH oxidase activation

Answer 30

Chronic Granulomatous Disease

Question 31

Tests for Digetsion

Answer 31

Nitrotetrazolium blue Test

Question 32

Interpretation: NBT Test

Blue Color - __________
No Color - __________

Answer 32

Interpretation: NBT Test

Blue Color - NADPH Activation
No Color - No Activation

Question 33

Process which antigen is excreted and undigested part (epitope) is presented to its surface to activate adaptive immunity

Answer 33

Exocytosis