Phagocytosis Flashcards
Process of Phagocytosis
Initiation Chemotaxis Recognition Ingestion Digestion Excretion
Oxidative Burst/Respiratory burst through engulfment of cell by wbcs
Phagocytosis
Process which cells adhere to the vascular system as a result of damage and trauma which increases surface receptors
Initiation
Cell receptors involved in the Initiation stage
CR3
Laminin receptor
Leucyl-formyl-methionyl phenylalanine receptors
Dominant phagocytic complement receptor in humans
CR3
Most potent PMN chemotactic factor;
Leucyl-formyl-methionyl phenylalanine receptors
Process which cells move to the site of injury under influence of chemotaxins
Chemotaxis
Potent chemo-attractants
C5a
C3a
Impaired chemotaxis
Job Syndrome
Lab Tests in Chemotaxis
Boyden Chamber Assay
Migration through Agarose gel
Process which cells discriminate self and non-self component
Recognition
2 mechanisms of Recognition
Direct Recognition
Indirect Recognition
Direct Recognition
Via:
Recognizes:
Direct Recognition
Via: Primitive Pattern Recognition Receptors
Recognizes: Pathogen Associated Molecular Patterns (PAMPS) on microorganisms
Indirect Recognition
Via:
Recognizes:
Indirect Recognition
Via: Opsonization
Recognizes: Opsonins coating the microorganisms
Most common Opsonins
C3b, iC3, C4b, IgG
______ coats/marks the microorganisms to facilitate increase phagocytosis by easily identifying antigens
Opsonins
Opsonins attach to the ______ of the antigens
Epitope
Antigenic determinant
Epitope
Process of cell eating which forms projections/cytoplasm extends out in the microorganisms
Ingestion
Steps in Ingestion
Pseudopod formation
Phagosome formation
Phagolysosome formation
_________ is a phagosome fused with cytoplasmic granules
Phagolysosome
Ingestion is enhanced by:
Opsonins
Surfuctants
Ingestion is inhibited by capsulated bacteria: ____________, ____________, ____________.
H. influenzae
S. pneumoniae
N. miningitidis
Microorganism inside the cell or a vacoule
Phagosome
