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Immunology-Serology > Acquired Immunity > Flashcards

Acquired Immunity Flashcards

1
Q

Refers to immune response following after encounter with antigen

A

Acquired/Adaptive Immunity/Secondary/Anamnestic

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2
Q

Characteristics of the Adaptive/Acquired Immunity

A

Specific

Memory

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3
Q

Cell mediated Immunity

Mechanism:
Cell Type:
Action:
Function:

A

Cell mediated Immunity

Mechanism: Cells
Cell Type: T cells
Action: Direct Cell-to-Cell contact
Function: Viral/Fungal Infections, Intracellular, Graft rejections

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4
Q

Humoral Mediated

Mechanism:
Cell Type:
Action:
Function:

A

Humoral Mediated

Mechanism: antibody Mediated
Cell Type: B cells, Plasma Cells
Action: Antibodies, Cytokines
Function: Bacterial infection

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5
Q

Tissues which immune cells undergo maturation, differentiation, proliferation

A

Lymphoid Tissues

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6
Q

Primary Lymphoid tissues

A

Bone Marrow

Thymus

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7
Q

Secondary Lymphoid Tissues

A

Spleen
Lymph Nodes
GALT, MALT

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8
Q

Location which undifferentiated and progenitor cells are derived responsible for the site of hematopoiesis

A

Bone marrow

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9
Q

Site of B cell maturation

A

Bone Marrow

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10
Q

Site of T cell maturation

A

Thymus

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11
Q

Primary Lymphoid Organs are involved in the ___________ of immune cells

A

Maturation

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12
Q

Secondary lymphoid organs are involved in the _____________ and __________ of immune cells

A

Differentiation

Proliferation

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13
Q

Antigen trapping sites or site of cell activation which its first encounter of the antigen

A

Secondary Lymphoid organ

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14
Q

Largest secondary lymphoid tissue

A

Spleen

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15
Q

Red Pulp - ______________

White Pulp - _____________

A

Red Pulp - RBCs sequestration (50%)

White Pulp - WBCs (20%)

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16
Q

PALS: ________
Primary Follicles: _________
Marginal Zones: __________

A

PALS: T cells
Primary Follicles: Undifferentiated/Resting B cells
Marginal Zones: Dendritic Cells

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17
Q

Major tissue portion which Antibody concentration

A

Lymph Nodes

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18
Q

Compartments

Primary Follicle:
Secondary Follicle:
Outer Cortex:
Paracortex:
Medulla:
A

Compartments

Primary Follicle: Resting B cells
Secondary Follicle: Ag-stimulated proliferating B cells
Outer Cortex: B cells
Paracortex: T cells
Medulla: Macrophages
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19
Q

Secondary lymphoid tissue involved in IgA production

A

MALT

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20
Q

Involved in the differentiation of progenitor cells into B lymphocytes

A

GALT

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21
Q

No/Lack CD4 and CD8

A

Double Negative Thymocytes

22
Q

Influence T cell proliferation

A

IL 7

23
Q

pre-TCR expression, _____ chain rearrangement takes first and once becomes functional it complexes with _____

A

pre-TCR expression, BETA chain rearrangement takes first and once becomes functional it complexes with CD3

24
Q

Main part in the T cell antigen receptor forming a complex

A

CD3

25
Q

Double Negative Thymocytes - Arrange

  1. pre-TCR expression
  2. B chain rearrangement
  3. Functional B chain complex with CD3
  4. Functional B chain
A

2 > 4 > 3 > 1

26
Q

Both CD4 and CD8 are expressed

A

Double Positive Thymocytes

27
Q

_____ chain rearrangement already begins in the double positive cells

A

alpha chain

28
Q

A selection process which double positive cell should recognize MHC class molecules

A

Positive Selection Process

29
Q

A selection process which double positive cell are checked if it strongly reacts against self antigens

A

Negative Selection Process

30
Q

A process in the expression of pre-TCR through random rearrangement causing to form a unique TCR (specific) even w/o antigen recognition yet

A

Somatic recombination

31
Q

Distribution:

CD4:
CD8:

A

Distribution:

CD4: 2/3
CD8: 1/3

32
Q

T helper Cell: ______

T Cytotoxic Cell: ______

A

T helper Cell: CD 4

T Cytotoxic Cell: CD 8

33
Q

T Cell MHC Class Restriction

CD4:
CD8:

A

MHC Class Restriction

CD4: MHC Class II
CD8: MHC Class I

34
Q

T Cell Activation

  1. TCR Conformation
  2. Antigen Presentation
  3. Releases IL 2 for proliferation and differentiation
  4. Activation of other T cells
A

T Cell Activation

2 > 1 > 3 > 4

35
Q

Receptor in sRBCs to form rosettes

A

CD 2

36
Q

Marker of mature T cells and part in TCR

A

CD 3

37
Q

Marker in Activated T cell

A

CD 25

38
Q

T Helper Subsets

Th1: __________
Th2: __________

A

Th1: INTRAcellular
Th2: EXTRAcellular

39
Q

Cytokines in T helper Subsets

Th1: __________
Th2: __________

A

Cytokines in T helper Subsets

Th1: IL 12, INFy, TNF-B
Th2: 1L 4, 1L 5, IL 10, 1L 13

40
Q

Earliest surface marker of B cells

A

CD 45R

41
Q

Marker - Pre-B Cell

A

mu chains; surrogate light chains

42
Q

Marker - Immature B Cell

A

IgM

MHC Class II

43
Q

Marker - Mature B Cells

A

IgM

IgD

44
Q

Marker - Activated B Cells

A

CD 25

45
Q

B cells that produces antibodies

A

Plasma Cells

46
Q

B cells with enhances speed and effectivity, and longer life span than resting b cells

A

Memory B cells

47
Q

First Manual identification of Lymphocytes - obsolete

A

Rosette Technique

48
Q

Rosette Technique

Principle:
Sample:
Reagent:
Result: 
Normal:
A

Rosette Technique

Principle: Density Gradient Concentration
Sample: Defibrinated/Heparinized Blood
Reagent: Sheep’s RBCs, Ficoll Hipaque Solution
Result: Rosette Formation
Normal: 2x as many of T cells than B cells

49
Q

A gradient solution that allow the separation of RBCs and granulocytes

A

Ficcol Hypaque

50
Q

Number of cells counted in Rosette Technique

A

200 cells

51
Q

Major Secretor of Cytokines

A

T helper cells

52
Q

Negative selection of T cells occurs in the ________________

A

Thymus. Negative selection of T cells occurs as they move from the thymic cortex into the thymic medulla

Immunology-Serology (15 decks)

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