Acquired Immunity

Question 1

Refers to immune response following after encounter with antigen

Answer 1

Acquired/Adaptive Immunity/Secondary/Anamnestic

Question 2

Characteristics of the Adaptive/Acquired Immunity

Answer 2

Specific

Memory

Question 3

Cell mediated Immunity

Mechanism:
Cell Type:
Action:
Function:

Answer 3

Cell mediated Immunity

Mechanism: Cells
Cell Type: T cells
Action: Direct Cell-to-Cell contact
Function: Viral/Fungal Infections, Intracellular, Graft rejections

Question 4

Humoral Mediated

Mechanism:
Cell Type:
Action:
Function:

Answer 4

Humoral Mediated

Mechanism: antibody Mediated
Cell Type: B cells, Plasma Cells
Action: Antibodies, Cytokines
Function: Bacterial infection

Question 5

Tissues which immune cells undergo maturation, differentiation, proliferation

Answer 5

Lymphoid Tissues

Question 6

Primary Lymphoid tissues

Answer 6

Bone Marrow

Thymus

Question 7

Secondary Lymphoid Tissues

Answer 7

Spleen
Lymph Nodes
GALT, MALT

Question 8

Location which undifferentiated and progenitor cells are derived responsible for the site of hematopoiesis

Answer 8

Bone marrow

Question 9

Site of B cell maturation

Answer 9

Bone Marrow

Question 10

Site of T cell maturation

Answer 10

Thymus

Question 11

Primary Lymphoid Organs are involved in the ___________ of immune cells

Answer 11

Maturation

Question 12

Secondary lymphoid organs are involved in the _____________ and __________ of immune cells

Answer 12

Differentiation

Proliferation

Question 13

Antigen trapping sites or site of cell activation which its first encounter of the antigen

Answer 13

Secondary Lymphoid organ

Question 14

Largest secondary lymphoid tissue

Answer 14

Spleen

Question 15

Red Pulp - ______________

White Pulp - _____________

Answer 15

Red Pulp - RBCs sequestration (50%)

White Pulp - WBCs (20%)

Question 16

PALS: ________
Primary Follicles: _________
Marginal Zones: __________

Answer 16

PALS: T cells
Primary Follicles: Undifferentiated/Resting B cells
Marginal Zones: Dendritic Cells

Question 17

Major tissue portion which Antibody concentration

Answer 17

Lymph Nodes

Question 18

Compartments

Primary Follicle:
Secondary Follicle:
Outer Cortex:
Paracortex:
Medulla:

Answer 18

Compartments

Primary Follicle: Resting B cells
Secondary Follicle: Ag-stimulated proliferating B cells
Outer Cortex: B cells
Paracortex: T cells
Medulla: Macrophages

Question 19

Secondary lymphoid tissue involved in IgA production

Answer 19

MALT

Question 20

Involved in the differentiation of progenitor cells into B lymphocytes

Answer 20

GALT

Question 21

No/Lack CD4 and CD8

Answer 21

Double Negative Thymocytes

Question 22

Influence T cell proliferation

Answer 22

IL 7

Question 23

pre-TCR expression, _____ chain rearrangement takes first and once becomes functional it complexes with _____

Answer 23

pre-TCR expression, BETA chain rearrangement takes first and once becomes functional it complexes with CD3

Question 24

Main part in the T cell antigen receptor forming a complex

Answer 24

CD3

Question 25

Double Negative Thymocytes - Arrange 1. pre-TCR expression 2. B chain rearrangement 3. Functional B chain complex with CD3 4. Functional B chain

Answer 25

2 > 4 > 3 > 1

Question 26

Both CD4 and CD8 are expressed

Answer 26

Double Positive Thymocytes

Question 27

_____ chain rearrangement already begins in the double positive cells

Answer 27

alpha chain

Question 28

A selection process which double positive cell should recognize MHC class molecules

Answer 28

Positive Selection Process

Question 29

A selection process which double positive cell are checked if it strongly reacts against self antigens

Answer 29

Negative Selection Process

Question 30

A process in the expression of pre-TCR through random rearrangement causing to form a unique TCR (specific) even w/o antigen recognition yet

Answer 30

Somatic recombination

Question 31

Distribution: CD4: CD8:

Answer 31

Distribution: CD4: 2/3 CD8: 1/3

Question 32

T helper Cell: ______ | T Cytotoxic Cell: ______

Answer 32

T helper Cell: CD 4 | T Cytotoxic Cell: CD 8

Question 33

T Cell MHC Class Restriction CD4: CD8:

Answer 33

MHC Class Restriction CD4: MHC Class II CD8: MHC Class I

Question 34

T Cell Activation 1. TCR Conformation 2. Antigen Presentation 3. Releases IL 2 for proliferation and differentiation 4. Activation of other T cells

Answer 34

T Cell Activation 2 > 1 > 3 > 4

Question 35

Receptor in sRBCs to form rosettes

Answer 35

CD 2

Question 36

Marker of mature T cells and part in TCR

Answer 36

CD 3

Question 37

Marker in Activated T cell

Answer 37

CD 25

Question 38

T Helper Subsets Th1: __________ Th2: __________

Answer 38

Th1: INTRAcellular Th2: EXTRAcellular

Question 39

Cytokines in T helper Subsets Th1: __________ Th2: __________

Answer 39

Cytokines in T helper Subsets Th1: IL 12, INFy, TNF-B Th2: 1L 4, 1L 5, IL 10, 1L 13

Question 40

Earliest surface marker of B cells

Answer 40

CD 45R

Question 41

Marker - Pre-B Cell

Answer 41

mu chains; surrogate light chains

Question 42

Marker - Immature B Cell

Answer 42

IgM | MHC Class II

Question 43

Marker - Mature B Cells

Answer 43

IgM | IgD

Question 44

Marker - Activated B Cells

Answer 44

CD 25

Question 45

B cells that produces antibodies

Answer 45

Plasma Cells

Question 46

B cells with enhances speed and effectivity, and longer life span than resting b cells

Answer 46

Memory B cells

Question 47

First Manual identification of Lymphocytes - obsolete

Answer 47

Rosette Technique

Question 48

Rosette Technique ``` Principle: Sample: Reagent: Result: Normal: ```

Answer 48

Rosette Technique Principle: Density Gradient Concentration Sample: Defibrinated/Heparinized Blood Reagent: Sheep's RBCs, Ficoll Hipaque Solution Result: Rosette Formation Normal: 2x as many of T cells than B cells

Question 49

A gradient solution that allow the separation of RBCs and granulocytes

Answer 49

Ficcol Hypaque

Question 50

Number of cells counted in Rosette Technique

Answer 50

200 cells

Question 51

Major Secretor of Cytokines

Answer 51

T helper cells

Question 52

Negative selection of T cells occurs in the ________________

Answer 52

Thymus. Negative selection of T cells occurs as they move from the thymic cortex into the thymic medulla