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Immunology-Serology > Introduction to Immune System > Flashcards

Introduction to Immune System Flashcards

1
Q

Study of Immune System and its mechanism

A

Immunology

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2
Q

2 Functions of Immune System

A
  1. Discriminate self from non-self

2. Eliminate non-self components

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3
Q

Roles of Immune system

A

Defend or protect against invading microorganism

Recognize and Respond to eliminate non-self component

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4
Q

Consequences of Immune System

A

Hypersensitivity Reactions (Allergy)
Graft rejection
Autoimmune diseases

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5
Q

Father of Immunology

A

Edward Jenner

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6
Q

Describe the process of phagocytosis

A

Ernst Hickel

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7
Q

Cellular Theory of Immunity through Phagocytosis

A

Elie Metchnikoff

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8
Q

Humoral Theory which was first proposed by:

A

Emil adolf von Behring

Shibasaburo Kitasato

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9
Q

Antibody Formation Theory

A

Paul Ehrlich

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10
Q

Innate Immunity

A

Present & active at Birth
Non-specific
Without memory

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11
Q

Adaptive/Acquired Immunity

A

Present at Birth
Specific
With Memory

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12
Q

True or False. Innate Immunity produces antibodies

A

False

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13
Q

True or False. Active Adaptive Immunity receives antibodies.

A

False. Active adaptive Immunity produces it own antibodies

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14
Q

True or False. Passive Adaptive Immunity produces its own antibody.

A

False. Passive Adaptive only receives antibody.

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15
Q

Present when body is having infection due to diseases or illness.

A

Natural Active Adaptive Immunity

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16
Q

Present when body receives antigen when inoculated with a vaccine, producing antibody.

A

Artificial Active Adaptive Antibody

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17
Q

Present when the body only receives antibodies from the mother through breastfeeding (Mother-to-Child)

A

Natural Passive Adaptive Immunity

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18
Q

Present when body receives antibody (ex. anti-rabies, anti-tetanus)

A

Artificial Passive Adaptive Immunity

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19
Q

Phase/Time which there is no action yet/activity first of the body to antigens of adaptive immunity.

A

Lag Phase

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20
Q

True or False. Adaptive Immunity are specific and diverse, that only respond to particular antigen that stimulated its response.

A

True.

21
Q

First line of Defence

A

Anatomical Barriers
Normal Flora
Genetic Influence

22
Q

Second Line of Defense

A

Cellular Factors

23
Q

Third Line of Defense

A

Lymphocytes

Antibodies

24
Q

More RAPID Body defense mechanism

A

Second Line of Defense

25
Q

Third line of Defense has a __________ mechanism of action.

A

Third line of Defense has a SLOWER mechanism of action.

26
Q

Third Line of Defense

Cellular:
Humoral:

A

Third Line of Defense

Cellular: Lymphocytes
Humoral: Antibodies

27
Q

ONLY WBCs not involved in second line of defense

A

Lymphocytes

28
Q

Cells involved in Allergic Reactions

A

Basophils

Eosinophils

29
Q

Cells involved in Phagocytosis

A

NK cells
PMNs
Monocyte-Macrophage

30
Q

Major inflammatory mediator released by Basophils

A

Histamine

31
Q

Basophils contains inflammatory mediators:
1.
2.
3.

A

Basophils contains inflammatory mediators:

  1. Histamine
  2. Heparin
  3. Eosinophil chemotactic factor
32
Q

Cell involved in Parasitic Infection

A

Eosinophil

33
Q

Receptors of Eosinophils

A

FcER

34
Q

Cell of the INNATE involved in killing virally infected cells and tumor cells

A

NK Cells

35
Q

Scavenger cells

A

Monocyte-macrophage

36
Q

Predominant WBC in Blood

A

Neutrophils (PMNs)

37
Q

Most POTENT antigen presenting cells

A

Dendritic Cells

38
Q

APCs

A

Dendritic Cells
Macrophage
B cells

39
Q

Site the Location

Kuppfer
Microglial
Histiocytes
Alveolar Macrophage
Splenic Macrophage
Mesangial
A

Site the Location

Kupffer - Liver
Microglial - CNS
Histiocytes - Connective Tissues
Alveolar Macrophage - Lungs
Splenic Macrophage - Spleen
Mesangial - Kidneys
40
Q

External immune defense system

A

First line of defense

41
Q

Components of the Anatomical Barrier

A 
Skin
Cillia
Mucus
Gastric acid
Earwax
Tears, Saliva
Urine pH, Flushing
42
Q

___________ prevents the multiplication of pathogens

A

Resident flora

43
Q

Resident Flora

Skin:
Oral Cavity:
Intestines:
Vagina:

A

Resident Flora

Skin: S. epidermidis
Oral Cavity: alpha hemolytic streptococcus, Viridans group
Intestines: Bacteriodes
Vagina: L. acidophiullus

44
Q

____________ have phenotypic expressions that affect the external immune defense system

A

Genetic influences

45
Q

Factors in the Genetic influence

A

Duffy null phenotype, P1 antigen

Inherited HLAs-b27: Ankylosing spondylitis

46
Q

Internal Defense System

A

Second Line of defense

47
Q

Primary response of the second line of defense

A

Phagocytosis

48
Q

Cellular Components in the 2nd line of defense

A 
PMNs
Monocyte/Macrophage
Eosinophil
Basophil/Mast cells
NK cells
Dendritic cells
APCs
49
Q

Humoral components in the 2nd line of defense

A 
APRs
TNF
Cytokines
INF
Betalysins
Complement

Immunology-Serology (15 decks)

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