Inflammation Flashcards
Tissue reaction to injury by physical or chemical agents
Inflammation
Inflammation involves __________ and __________ response by the tissues of the body in response to injury
Cellular response
Vascular response
Cardinal Signs
Rubor; \_\_\_\_\_\_\_\_\_ Calor: \_\_\_\_\_\_\_\_\_ Dolor: \_\_\_\_\_\_\_\_ Tumor: \_\_\_\_\_\_\_\_\_ Function Laesa: \_\_\_\_\_\_\_\_\_
Cardinal Signs
Rubor; Redness Calor: Heat production (Hypermia) Dolor: Pain Tumor: Swelling Function Laesa: Loss of function
Mechanism in the Vascular Response
- Increase release of Histamine
- Vasodilation
- Increase blood Flow
- Rubor and Calor
- Increase capillary permeability
- Plasma leakage to tissue
- Tumor and Dolor
Mechanism in Cellular Response
- 30 - 60 mins - PMNs
- Peak in 16-18 hrs - Macrophages
- APRs: CRP/Serum amyloid > AAP/Fibrinogen > Haptoglobin > Ceruloplasmin/C3
Mechanism in Repair
Increase Fibroblast proliferation
- Total repair
- Abcess/Loss of function
- Granuloma
Pain
Dolor
Heat
Calor
Tumor
Swelling
Dolor
Pain
Vascular response (vasodilation) is initiated by through release of ___________
Histamine
Migrate 30-60 minutes in the site of injury
PMNs
Dominant cells in acute stage
PMNs
Macrophage peak hours in inflammation
16-18 hrs
APRs which responds in 24 hrs
Serum amyloid A
AAP
Fibrinogen
Haptoglobin
Most potent APRs that respond within 6-10 hrs
CRP
APRs that responds 48-74 hrs
Ceruloplasmin C3
APRs increased in 1000x
CRP
Serum amyloid A
APRs increased 2-5x
AAP
Fibrinogen
APRs increased 2-10x
Haptoglobin
APRs increased 2X
C3
Ceruloplasmin