Inflammation Flashcards

1
Q

Tissue reaction to injury by physical or chemical agents

A

Inflammation

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2
Q

Inflammation involves __________ and __________ response by the tissues of the body in response to injury

A

Cellular response

Vascular response

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3
Q

Cardinal Signs

Rubor; \_\_\_\_\_\_\_\_\_
Calor: \_\_\_\_\_\_\_\_\_
Dolor: \_\_\_\_\_\_\_\_
Tumor: \_\_\_\_\_\_\_\_\_
Function Laesa: \_\_\_\_\_\_\_\_\_
A

Cardinal Signs

Rubor; Redness
Calor: Heat production (Hypermia)
Dolor: Pain
Tumor: Swelling
Function Laesa: Loss of function
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4
Q

Mechanism in the Vascular Response

A
  1. Increase release of Histamine
  2. Vasodilation
  3. Increase blood Flow
  4. Rubor and Calor
  5. Increase capillary permeability
  6. Plasma leakage to tissue
  7. Tumor and Dolor
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5
Q

Mechanism in Cellular Response

A
  1. 30 - 60 mins - PMNs
  2. Peak in 16-18 hrs - Macrophages
  3. APRs: CRP/Serum amyloid > AAP/Fibrinogen > Haptoglobin > Ceruloplasmin/C3
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6
Q

Mechanism in Repair

A

Increase Fibroblast proliferation

  1. Total repair
  2. Abcess/Loss of function
  3. Granuloma
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7
Q

Pain

A

Dolor

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8
Q

Heat

A

Calor

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9
Q

Tumor

A

Swelling

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10
Q

Dolor

A

Pain

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11
Q

Vascular response (vasodilation) is initiated by through release of ___________

A

Histamine

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12
Q

Migrate 30-60 minutes in the site of injury

A

PMNs

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13
Q

Dominant cells in acute stage

A

PMNs

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14
Q

Macrophage peak hours in inflammation

A

16-18 hrs

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15
Q

APRs which responds in 24 hrs

A

Serum amyloid A
AAP
Fibrinogen
Haptoglobin

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16
Q

Most potent APRs that respond within 6-10 hrs

A

CRP

17
Q

APRs that responds 48-74 hrs

A

Ceruloplasmin C3

18
Q

APRs increased in 1000x

A

CRP

Serum amyloid A

19
Q

APRs increased 2-5x

A

AAP

Fibrinogen

20
Q

APRs increased 2-10x

A

Haptoglobin

21
Q

APRs increased 2X

A

C3

Ceruloplasmin