PD Drugs Flashcards
drugs are given to improve pt’s ability to do ____
ADL’s
drugs are prescribed by they extent of how the disease affects the pt’s ___ & ____’s
work
ADL’s
what is the most common pd dug
levodopa
levodopa is highly effective but____ over time
diminishes
what delays levodopa absorption
food
what foods can reduce levodopa’s therapeutic effects
high protein foods
what are adverse effects of levodopa/carbidopa (8)
N/V
dyskinesias
postural hypotension
dysrhythmias
psychosis
impulse control
darkened sweat & urine
loss of effect
what is the 1st drug of choice for mild to moderate symps
dopemine agonists
what med is a dopamine agonist
pramipexole
pramipexole is used ____ in early PD
alone
pramipexole is used with levodopa in _____ PD
advanced
what are adverse effects of pramipexole when used by itself (8)
SLEEP ATTACKS***
nausea
dizziness
daytime somnolence
insomnia
constipation
weakness
hallucinations
when levodopa & pramipexole are used in combination what are the adverse effects (3)
orthostatic hypotension
dyskinesia
increased hallucinations
what two meds are anticholinergics
trihexiphenidyl
benztropine
what are adverse effects of anticholinergics (8)
dry mouth
urinary retention
tachycardia
blurred vision
constipation
photophobia
confusion
hallucinations
COMT inhibitors help with the metabolism of _____ in the periphery
levodopa
what are the two COMT inhibitors available
entacapone
tolcapone
what are the adverse effects of entacapone (7)
dyskinesia
orthostatic hypotension
N/V/D
hallucinations
sleep disturbances
impulse control disorders
yellow-orange discoloration of urine
what are adverse effects of tolcapone (7)
liver failure
dyskinesia
orthostatoc hypotension
hallucinations
sleep disturbances
yellow-orange urine \
MAOB-B Inhibitors are considered ____ drugs for PD
first-line
what are the two MAO-B inhibitors
selegiline
rasagiline
selegiline can be used ____ or w/ ____
alone
levodopa
what are the adverse effects of selegiline (6)
insomnia
dry mouth
orthostatic hypotension
dizziness
hypertensive crisis
GI symps
rasagiline can be used ____ or w/ _____
alone
levodopa
what are the adverse effects of rasagiline (4)
insomnia
orthostatic hypotension
irritation of buccal mucosa
hypertension crisis
