Pathophysiology of infections and clinical infection markers Flashcards
1
Q
Mechanism of pathogen-host interaction: Adherence
A
- Pili/fimbriae
- Ahesion
- Biofilm
- Hide from host immune systems
2
Q
Mechanism of pathogen-host interaction:
immune invasion
A
- Antigenic variation
- Intracellular survival
- Inhibit phagocytosis
3
Q
Mechanism of pathogen-host interaction: tissue damage
A
- Toxins
- Inflammation and host cell death
3
Q
Infection pathogenesis: Listeria monocytogenes
A
- Pathogen colonises establishes residance at site of infection
- Invasion breach host barriers gaining access to deeper tissue
- Proliferation by multiplying and spreding with host
- Dissemination - Spred to other sites within host or to new host
(Host defence gone cause septacemia)
4
Q
Pathology
A
- Condition during a diseased state
5
Q
physiology
A
- Physological process and mechanism operating within an organism
6
Q
Pathophysology
A
- Functional changes that ae occouring in an indavidual due to a disease
7
Q
Nosocomal
A
- Hospital contracted condition
8
Q
Risk factors
A
- A factor when present increases likelihood of diseases
9
Q
Pathogenesis
A
- Evolution of disease from the inital stimulus to manifestation of disease
10
Q
Preclinical phase
A
- Biological onset of disease
- Symptoms appear
11
Q
Clinical phase
A
- Diagnosis
- Therapy begun
- Outcome cured or living with disease
12
Q
Clinical manifestation
A
- Symptoms - feeling headache, hot and generally unwell
- Signs - Measureable such as temperature
- Syndrome - diagnosis toxic shock
13
Q
A
14
Q
Three systemic effects of infection
A
- Increased temperature >38 degrees infectious or non-infectious causes inflammation
- Fever is mediated by pyrogenic activity of prostaglandin such Pge2
- Peg2 stimulates endogenous pyrogens such as IL1 and IL6, tumour necrosis and interferon
- Endogenous pyrogens trigger immune and inflammatory response - leukocytes, T cell active and b cell proliferation and increase WB adhesion
