Pathology of Rashes Flashcards
what do langerhans cells do?
process and gather antigens to intiate inflammation
where are langerhans cells found?
upper and mid-epidermis
what do melanocytes look like under a microscope?
pale with a halo around them
what does hyperkeratosis mean?
increased thickness of the keratin layer
what does parakeratosis mean?
persistence of nuclei in the keratin layer as a result of cells maturing too quickly
what does acanthosis mean?
increased thickness of epithelium
what does papillomatosis mean?
irregular epithelial thickening
what does spongiosis mean?
oedematous fluid between cells in the epidermis
name the 4 main types of inflammatory skin disease
spongiotic i.e “the eczemas”
psoriasiform
lichenoid
vesiculobullous
what pathogenicity would you see on histology of psoriasis?
epidermal hyperplasia (increased epidermal turnover)
what pathogenicity is common to all lichenoid disorders?
damage to the basal layer of the epidermis
histology presentation of lichen planus?
irregular sawtooth acanthosis
hypergranulosis
lymphocytes in upper dermis
basal layer damage
clinical presentation of lichen planus
small itchy papules on skin
wickham’s striae => pallor in buccal mucosa
does acantholysis occur in pemphigus or pemphygoid?
pemphigus
what immunobullous condition is associated with coeliac disease?
dermatitis herpetiformis
